2-phenoxy-6-(4-(trifluoromethyl)phenyl)pyridine | 1423231-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-phenoxy-6-(4-(trifluoromethyl)phenyl)pyridine
• 英文别名: 2-Phenoxy-6-[4-(trifluoromethyl)phenyl]pyridine；2-phenoxy-6-[4-(trifluoromethyl)phenyl]pyridine
• CAS: 1423231-39-3
• 化学式: C₁₈H₁₂F₃NO
• 分子量: 315.295
• InChiKey: HDZBYRDXUZOQCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-(4-(三氟甲基)苯基)吡啶-2-醇 、 苯硼酸 在 三乙烯二胺 、 potassium dihydrogenphosphate 、 copper(II) bis(trifluoromethanesulfonate) 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以58%的产率得到2-phenoxy-6-(4-(trifluoromethyl)phenyl)pyridine
  参考文献：
  名称：

  Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones

  摘要：

  A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin-2-ones with a series of arylboronic acids, using Cu(OTf)(2) as the catalyst, DABCO as the ligand, Et3N as the base, and K2HPO4 as the additive. This method affords O-arylated pyridin-2-ones with good selectivity and yields (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.12.126

文献信息

• Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones
  作者：Taijie Chen、Qingqing Huang、Yu Luo、Youhong Hu、Wei Lu

  DOI：10.1016/j.tetlet.2012.12.126

  日期：2013.3

  A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin-2-ones with a series of arylboronic acids, using Cu(OTf)(2) as the catalyst, DABCO as the ligand, Et3N as the base, and K2HPO4 as the additive. This method affords O-arylated pyridin-2-ones with good selectivity and yields (C) 2013 Elsevier Ltd. All rights reserved.