(2S,4R)-4-(butylcarbamoyloxy)pyrrolidine-2-carboxylic acid | 1215232-87-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4R)-4-(butylcarbamoyloxy)pyrrolidine-2-carboxylic acid
• CAS: 1215232-87-3
• 化学式: C₁₀H₁₈N₂O₄
• 分子量: 230.264
• InChiKey: PEIWMFXXFJWPFN-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S,4R)-dibenzyl 4-(butylcarbamoyloxy)pyrrolidine-1,2-dicarboxylate 在 palladium 10% on activated carbon 、 环己烯 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以35%的产率得到(2S,4R)-4-(butylcarbamoyloxy)pyrrolidine-2-carboxylic acid
  参考文献：
  名称：

  Silica-supported l-proline organocatalysts for asymmetric aldolisation

  摘要：

  New heterogenised silica-based organocatalysts have been prepared via the sol-gel process from two silylated derivatives Of L-proline, featuring either a carbamate or an ether linker. Co-gelification with variable amounts of TEOS was performed with and without porogen to yield high surface area solids. These materials were evaluated as heterogeneous phase organocatalysts for the asymmetric aldol reaction of p-nitrobenzaldehyde with acetone. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.11.024

文献信息

• Silica-supported l-proline organocatalysts for asymmetric aldolisation
  作者：Alexandra Zamboulis、Nicolas J. Rahier、Matthias Gehringer、Xavier Cattoën、Gilles Niel、Catherine Bied、Joël J.E. Moreau、Michel Wong Chi Man

  DOI：10.1016/j.tetasy.2009.11.024

  日期：2009.12

  New heterogenised silica-based organocatalysts have been prepared via the sol-gel process from two silylated derivatives Of L-proline, featuring either a carbamate or an ether linker. Co-gelification with variable amounts of TEOS was performed with and without porogen to yield high surface area solids. These materials were evaluated as heterogeneous phase organocatalysts for the asymmetric aldol reaction of p-nitrobenzaldehyde with acetone. (C) 2009 Elsevier Ltd. All rights reserved.