methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid | 748155-18-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
• CAS: 748155-18-2
• 化学式: C22H28ClNO9S
• 分子量: 518.0
• InChiKey: MLQFCIFJJUDBLY-UHXDFYNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.18
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  196
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS
  申请人：Nadkarni, Sunil Sadanand

  公开号：EP1606231A1

  公开（公告）日：2005-12-21
• PHARMACEUTICAL COMPOSITIONS OF CLOPIDOGREL
  申请人：Wockhardt Limited

  公开号：EP2148655B1

  公开（公告）日：2013-02-27
• Pharmaceutical formulation for salts of monobasic acids with clopidogrel
  申请人：Doser Karl-Heinz

  公开号：US20070048370A1

  公开（公告）日：2007-03-01

  A pharmaceutical formulation in the form of a tablet which contains, as active substance, a salt of a monobasic acid with clopidogrel is disclosed herein.
• [EN] PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] PROCEDE DE PREPARATION DE CLOPIDOGREL, SES SELS ET COMPOSITIONS PHARMACEUTIQUES
  申请人：NADKARNI SUNIL SADANAND

  公开号：WO2004074215A1

  公开（公告）日：2004-09-02

  The invention discloses an improved process for racemization of methyl (R)­(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha­ (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
• [EN] PHARMACEUTICAL COMPOSITIONS OF CLOPIDOGREL<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE CLOPIDOGREL
  申请人：WOCKHARDT RESEARCH CENTER

  公开号：WO2008129468A2

  公开（公告）日：2008-10-30

  (EN) The invention relates to pharmaceutical compositions comprising clopidogrel or monobasic acid salts thereof in admixture with one or more hydrated excipients. The invention also relates to pharmaceutical compositions comprising clopidogrel or monobasic acid salts thereof which are free of any moisture scavenger. The invention also relates to processes for the preparation of such compositions.(FR) La présente invention concerne des compositions pharmaceutiques comportant du clopidogrel ou de ses sels monobasiques dans un mélange avec un ou des excipients hydratés. L'invention concerne également des compositions pharmaceutiques comportant du clopidogrel ou de ses sels monobasiques exemptes de tout capteur d'humidité. L'invention concerne en outre des procédés de préparation de telles compositions.