N-{D,L-2-(hydroxyaminocarbonyl)methyl-4-methylpentanoyl}-L-3-(2'-naphthyl)alanyl-L-alanine | 221147-98-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{D,L-2-(hydroxyaminocarbonyl)methyl-4-methylpentanoyl}-L-3-(2'-naphthyl)alanyl-L-alanine
• 英文别名: (2S)-2-[[(2S)-2-[[2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]propanoic acid
• CAS: 221147-98-4
• 化学式: C₂₄H₃₁N₃O₆
• 分子量: 457.527
• InChiKey: AYXUWDWQELVKCO-VBSNWNEZSA-N

物化性质

• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Soft tissue implants and anti-scarring agents
  申请人：Hunter L. William

  公开号：US20050142162A1

  公开（公告）日：2005-06-30

  Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.

  软组织植入物（例如乳房、胸肌、下巴、面部、唇部和鼻部植入物）与抗瘢痕剂结合使用，以抑制动物体内植入物放置时可能发生的瘢痕形成。
• Statin-MMP inhibitor combinations
  申请人：——

  公开号：US20020049237A1

  公开（公告）日：2002-04-25

  The invention is a pharmaceutical composition comprising an MMP inhibitor and a statin, said composition being useful for treating vascular diseases.

  这项发明是一种药物组合物，包括MMP抑制剂和他汀类药物，该组合物可用于治疗血管疾病。
• Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing
  申请人：WARNER-LAMBERT COMPANY LLC

  公开号：EP1366765A1

  公开（公告）日：2003-12-03

  Matrix metalloproteinase inhibitors are useful for preventing and treating neurological disorders and in promoting wound healing.

  基质金属蛋白酶抑制剂可用于预防和治疗神经系统疾病以及促进伤口愈合。
• Drug delivery from rapid gelling polymer composition
  申请人：ANGIOTECH INTERNATIONAL AG

  公开号：EP2181704A2

  公开（公告）日：2010-05-05

  Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in prevention of surgical adhesions.

  本发明公开了一些组合物，这些组合物由两部分聚合物组成，在混合在一起时可迅速形成共价连接，从而实现药物输送。当需要快速粘附组织和形成凝胶并同时给药时，这种组合物特别适合用于各种与组织相关的应用。例如，这种组合物可用作组织密封剂、促进止血、实现组织粘合、提供组织增量以及防止手术粘连。
• Mammalian TNF-alpha convertases
  申请人：——

  公开号：US20020106781A1

  公开（公告）日：2002-08-08

  The present invention provides isolated human and bovine TNF-&agr; convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-&agr;. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-&agr; convertases, and for identifying nucleic acids encoding such convertases.

  本发明提供了分离的人和牛 TNF-&agr; 转化酶、编码这些转化酶的核酸和重组载体、包含这些核酸和载体的宿主细胞，以及使用这些宿主细胞制造转化酶的方法。本发明进一步提供了抗体及其抗原结合片段，它们能特异性地与转化酶结合，可用于治疗由 TNF-&agr 引起或介导的病症。本发明还提供了用于鉴定哺乳动物 TNF-&agr; 转化酶特异性抑制剂的筛选方法，以及用于鉴定编码此类转化酶的核酸的筛选方法。