tert-butyl N-[8-[(2-methylpropan-2-yl)oxycarbonylamino]-3,4-bis[4-[(2-methylpropan-2-yl)oxycarbonylamino]but-1-ynyl]oct-3-en-5-ynyl]carbamate | 1579287-12-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[8-[(2-methylpropan-2-yl)oxycarbonylamino]-3,4-bis[4-[(2-methylpropan-2-yl)oxycarbonylamino]but-1-ynyl]oct-3-en-5-ynyl]carbamate
• CAS: 1579287-12-9
• 化学式: C₃₆H₅₆N₄O₈
• 分子量: 672.863
• InChiKey: PWPJSPCVARKQCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  48
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-BOC-丁氰-4-胺 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 正丁胺 作用下， 以 苯 为溶剂， 以60%的产率得到di-tert-butyl octa-3,5-diyne-1,8-diyldicarbamate
  参考文献：
  名称：

  Palladium(II)–copper(I) mediated homotrimerization and homotetramerization of terminal alkynes

  摘要：

  Alkyne homocoupling is commonly observed in cross coupling reactions; however, self trimerization and homotetramerization of alkynes to form branched products through cross-coupling reactions are rarely reported. We describe herein homotrimerization and homotetramerization of terminal alkynes under the Sonogashira reaction conditions that gave the corresponding modified enediynes. Substrate scope for this reaction was explored. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.146

文献信息

• Palladium(II)–copper(I) mediated homotrimerization and homotetramerization of terminal alkynes
  作者：Ravi Shekar Yalagala、Ningzhang Zhou、Hongbin Yan

  DOI：10.1016/j.tetlet.2014.01.146

  日期：2014.3

  Alkyne homocoupling is commonly observed in cross coupling reactions; however, self trimerization and homotetramerization of alkynes to form branched products through cross-coupling reactions are rarely reported. We describe herein homotrimerization and homotetramerization of terminal alkynes under the Sonogashira reaction conditions that gave the corresponding modified enediynes. Substrate scope for this reaction was explored. (c) 2014 Elsevier Ltd. All rights reserved.