2-p-tolyl-7H-chromeno[6,5-d]thiazol-7-one | 1447949-97-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-p-tolyl-7H-chromeno[6,5-d]thiazol-7-one
• 英文别名: 2-(4-Methylphenyl)pyrano[2,3-g][1,3]benzothiazol-7-one；2-(4-methylphenyl)pyrano[2,3-g][1,3]benzothiazol-7-one
• CAS: 1447949-97-4
• 化学式: C₁₇H₁₁NO₂S
• 分子量: 293.346
• InChiKey: IDMFQIVHBLOZTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(5-bromo-2-oxo-2H-chromen-6-yl)-4-methylbenzamide 在 sodium sulfide 、 iron(III) chloride 、 盐酸 作用下， 以 N,N-二甲基甲酰胺 、 水 为溶剂， 反应 12.0h， 以86%的产率得到2-p-tolyl-7H-chromeno[6,5-d]thiazol-7-one
  参考文献：
  名称：

  An efficient synthesis of coumarin- and quinolone-annulated thiazole derivatives via ligand-free iron (III)-catalyzed coupling followed by acid-promoted condensation

  摘要：

  An efficient strategy for the synthesis of coumarin- and quinolone-annulated thiazole derivatives using sodium sulfide as a sulfur source has been achieved via ligand-free iron (III)-catalyzed coupling followed by acid-promoted condensation. This synthetic protocol is one-pot, less expensive, and affords the products in good yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.017

文献信息

• An efficient synthesis of coumarin- and quinolone-annulated thiazole derivatives via ligand-free iron (III)-catalyzed coupling followed by acid-promoted condensation
  作者：K.C. Majumdar、Debankan Ghosh

  DOI：10.1016/j.tetlet.2013.06.017

  日期：2013.8

  An efficient strategy for the synthesis of coumarin- and quinolone-annulated thiazole derivatives using sodium sulfide as a sulfur source has been achieved via ligand-free iron (III)-catalyzed coupling followed by acid-promoted condensation. This synthetic protocol is one-pot, less expensive, and affords the products in good yields. (C) 2013 Elsevier Ltd. All rights reserved.