6-chloro-2,2-trimethylenehexanoic acid | 199592-86-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-chloro-2,2-trimethylenehexanoic acid
• 英文别名: 1-(4-Chlorobutyl)cyclobutane-1-carboxylic acid
• CAS: 199592-86-4
• 化学式: C₉H₁₅ClO₂
• 分子量: 190.67
• InChiKey: KIIFIJDXESIMON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel anilide compounds and pharmaceutical compositions comprising them
  申请人：——

  公开号：US20020037910A1

  公开（公告）日：2002-03-28

  The invention provides novel anilide compounds and pharmaceutical compositions comprising them. The invention relates to compounds of a formula: 1 wherein Ar is an optionally-substituted aryl group; R 4 and R 5 are the same or different, and each is a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and R 4 and R 5 may together form a lower alkylene group of which one or more methylene moieties may optionally be substituted by oxygen and/or sulfur atoms; X is —NH—, or an oxygen or sulfur atom; Y is —NH—, an oxygen or sulfur atom, or a sulfoxide or sulfone group; Z is a single bond, or —NR 6 —; R 6 represents a hydrogen atom or a lower alkylene group; and n is an integer of from 0 to 15; and their salts and solvates. The compounds of the invention are useful as pharmaceutical compositions, especially as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitors.

  本发明提供了新型苯甲酰胺类化合物及其制备的药物组合物。本发明涉及一种公式1的化合物：其中Ar是可选取的取代芳基基团；R4和R5相同或不同，每个为氢原子、低碳基基团或低氧基基团；R4和R5可以共同形成一个低碳基烷基，其中一个或多个亚甲基团可以选择性地被氧和/或硫原子取代；X为—NH—或氧或硫原子；Y为—NH—、氧或硫原子或亚砜基或砜基团；Z为单键或—NR6—；R6表示氢原子或低碳基烷基；n为0至15的整数；以及它们的盐和溶剂化物。本发明的化合物可用作药物组合物，特别是作为酰基辅酶A胆固醇酰基转移酶（ACAT）抑制剂。
• Anilide compounds as ACAT inhibitors
  申请人：KOWA COMPANY LTD.

  公开号：EP0807627A2

  公开（公告）日：1997-11-19

  The invention provides novel anilide compounds and pharmaceutical compositions comprising them. The invention relates to compounds of a formula: where Ar is an optionally-substituted aryl group; R4 and R5 are the same or different, and each is a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and R4 and R5 may together form a lower alkylene group of which one or more methylene moieties may optionally be substituted by oxygen and/or sulfur atoms; X is -NH-, or an oxygen or sulfur atom; Y is -NH-, an oxygen or sulfur atom, or a sulfoxide or sulfone group; Z is a single bond, or -NR6-; R6 represents a hydrogen atom or a lower alkylene group; and n is an integer of from 0 to 15; and their salts and solvates. The compounds of the invention are useful as pharmaceutical compositions, especially as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitors.

  本发明提供了新型苯胺化合物及其药物组合物。 本发明涉及式如下的化合物： 其中 Ar 是任选取代的芳基； R4 和 R5 相同或不同，且各自为氢原子、低级烷基或低级烷氧基；R4 和 R5 可共同形成低级亚烷基，其中一个或多个亚甲基可任选被氧原子和/或硫原子取代； X 是-NH-、氧原子或硫原子； Y 是-NH-、氧原子或硫原子、亚砜或砜基； Z 是单键，或 -NR6-； R6 代表氢原子或低级亚烷基；以及 n 是 0 至 15 的整数； 以及它们的盐和溶剂。 本发明的化合物可用作药物组合物，尤其是酰基辅酶 A 胆固醇酰基转移酶（ACAT）抑制剂。
• US6204278B1
  申请人：——

  公开号：US6204278B1

  公开（公告）日：2001-03-20
• US6825223B2
  申请人：——

  公开号：US6825223B2

  公开（公告）日：2004-11-30