3-amino-6,6-dimethyl-azepan-2-one | 64442-19-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-6,6-dimethyl-azepan-2-one
• 英文别名: 3-Amino-6,6-dimethylazepan-2-one
• CAS: 64442-19-9
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: DAAUVPACSPNLFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-amino-6,6-dimethyl-azepan-2-one 生成 2,6-diamino-5,5-dimethylhexanoic acid
  参考文献：
  名称：

  胶原蛋白生物合成的潜在抑制剂。5,5-二氟-DL-赖氨酸和5,5-二甲基-DL-赖氨酸及其通过赖氨酰-tRNA连接酶的活化。

  摘要：

  描述了赖氨酸类似物的合成，其中在5位被肽基赖氨酸羟化酶羟化的位置取代了封闭基团。因此，从酮前体开始，分别通过四步和六步顺序合成了5,5-二氟赖氨酸（1）和5,5-二甲基赖氨酸（2）。通过在体外赖氨酸-tRNA连接酶存在下刺激赖氨酸依赖性ATP-PPi交换反应的能力，评估了这些赖氨酸类似物在体内掺入前胶原蛋白的倾向。二氟类似物1刺激了交换，但Km（1.3 X 10（-3）M）比赖氨酸本身的交换活性大1000倍。二甲基类似物2不会刺激交换，但在高浓度下是竞争性的赖氨酸抑制剂，表观Ki值为1.6 X 10（-2）M。

  DOI：

  10.1021/jm00222a017

文献信息

• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Thorsett D. Eugene

  公开号：US20070203108A1

  公开（公告）日：2007-08-30

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及抑制β-淀粉样肽的释放和/或合成的化合物，因此在治疗阿尔茨海默病方面具有用途。同时，本发明还涉及包含抑制β-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这些药物组合物预防和治疗阿尔茨海默病的方法。
• Enzymatic deprotection of amines and hydroxides
  申请人：——

  公开号：US20020123110A1

  公开（公告）日：2002-09-05

  Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H—(CH 2 ) n —O—C(═O)— where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

  本发明提供了一种对被式中基团保护的氢氧化物或胺进行脱保护的方法 ArC*(R)H-(CH 2 ) n -O-C(═O)-取代基如下所述。 其中取代基如下所述，该方法包括：将受保护的氢氧化物或胺与有效去除保护基的酶接触；以及回收胺。还提供了一种分离产生有效去除保护基的酶的细菌的方法，该方法包括：在具有生长选择量的胺化合物的培养基上生长预期细菌，该胺化合物如上所述被保护；分离在所述培养基上生长的细菌。
• ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES
  申请人：Bristol-Myers Squibb Company

  公开号：EP1348025A2

  公开（公告）日：2003-10-01
• N-CARBOBENZYLOXY (N-CBZ)-DEPROTECTING ENZYME AND USES THEREFOR
  申请人：Nanduri B. Venkata

  公开号：US20060149047A1

  公开（公告）日：2006-07-06

  This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.
• N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor
  申请人：Nanduri B. Venkata

  公开号：US20060275878A1

  公开（公告）日：2006-12-07

  This invention relates to isolated or recombinant N—CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N—CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.