Glycol(di-β-acetylaminoethyl)ether | 5538-93-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glycol(di-β-acetylaminoethyl)ether
• 英文别名: 1,8-bis-acetamido-3,6-dioxa-octane；N-[2-[2-(2-acetamidoethoxy)ethoxy]ethyl]acetamide
• CAS: 5538-93-2
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: BFEOXSZBXGCZOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS
  申请人：THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH

  公开号：US20160159754A1

  公开（公告）日：2016-06-09

  Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.

  本文描述了用于治疗囊性纤维化的化合物、组成物及其使用方法。
• Radioactively-labeled somatostatin derived peptides for imaging and therapeutics uses
  申请人：Diatide, Inc.

  公开号：EP1092726A2

  公开（公告）日：2001-04-18

  This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (186Re) and rhenium-188 (188Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.

  本发明涉及治疗试剂和肽，包括放射性治疗试剂和肽、放射性诊断试剂和肽，以及生产标记放射性诊断剂的方法。具体地说，本发明涉及体生长抑素的环肽衍生物和类似物，以及用放射性同位素进行放射性标记的这种肽的实施方案，以及制造、放射性标记和使用这种肽用于放射诊断和放射治疗目的的方法和试剂盒。本发明具体涉及用锝-99m 放射性标记的环肽衍生物和体生长抑素类似物及其作为闪烁成像剂的用途。本发明还特别涉及用铼-186（186Re）和铼-188（188Re）等细胞毒性放射性同位素放射性标记的环肽衍生物和类似物，用作放射治疗剂。此外，还提供了用于制造、放射性标记和在哺乳动物体内诊断和治疗使用这种肽的方法和试剂盒。
• Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
  申请人：Diatide, Inc.

  公开号：EP1099707A2

  公开（公告）日：2001-05-16

  This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (186Re) and rhenium-188 (188Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.

  本发明涉及治疗试剂和肽，包括放射性治疗试剂和肽、放射性诊断试剂和肽，以及生产标记放射性诊断剂的方法。具体地说，本发明涉及体生长抑素的环肽衍生物和类似物，以及用放射性同位素进行放射性标记的这种肽的实施方案，以及制造、放射性标记和使用这种肽用于放射诊断和放射治疗目的的方法和试剂盒。本发明具体涉及用锝-99m 放射性标记的环肽衍生物和体生长抑素类似物及其作为闪烁成像剂的用途。本发明还特别涉及用铼-186（186Re）和铼-188（188Re）等细胞毒性放射性同位素放射性标记的环肽衍生物和类似物，用作放射治疗剂。此外，还提供了用于制造、放射性标记和在哺乳动物体内诊断和治疗使用这种肽的方法和试剂盒。
• Enhanced scintigraphic imaging agents for imaging of infection and inflammation
  申请人：Schering AG

  公开号：EP1437145A1

  公开（公告）日：2004-07-14

  The invention describes enhanced scintigraphic imaging agents that can be used to localize infection and inflammation in a mammal. Specifically, the invention relates to radiolabeled, preferably technetium-99m labeled scintigraphic imaging agents that are compositions of a polysulfated glycan or mixture thereof and a compound comprising a polybasic peptide covalently linked to a radiolabel binding moiety. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body are also provided. The enhanced imaging agents exhibit improved binding affinity to the polysulfated glycans, better biodistribution and infection uptake, thus providing improved imaging results.

  本发明描述了可用于定位哺乳动物感染和炎症的增强闪烁成像剂。具体地说，本发明涉及放射性标记的，最好是锝-99m 标记的闪烁成像剂，它是由多硫酸化聚糖或其混合物和包含与放射性标记结合分子共价连接的多基肽的化合物组成的组合物。此外，还提供了制造这种组合物的方法和试剂盒，以及使用这种组合物对哺乳动物体内感染和炎症部位成像的方法。增强型成像剂与多硫化聚糖的结合亲和力得到改善，生物分布和感染吸收也得到改善，从而提供更好的成像效果。
• TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION
  申请人：Diatide, Inc.

  公开号：EP0702570B1

  公开（公告）日：1999-08-04