(R)-6,6-difluoro-5-(2-fluorophenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine | 1393802-45-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-6,6-difluoro-5-(2-fluorophenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine
• 英文别名: (5R)-6,6-difluoro-5-(2-fluorophenyl)-5-methyl-2,7-dihydro-1,4-oxazepin-3-amine
• CAS: 1393802-45-3
• 化学式: C₁₂H₁₃F₃N₂O
• 分子量: 258.243
• InChiKey: OKINJGDBLUHTFZ-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS<br/>[FR] 1,4-OXAZÉPINES EN TANT QU'INHIBITEURS DE BACE1 ET/OU BACE2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012110459A1

  公开（公告）日：2012-08-23

  This invention relates to compounds of the formula wherein and R1 to R3 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

  这项发明涉及以下式中的化合物，其中R1至R3如下所述，或其药学上可接受的盐。这些化合物是BACE1和/或BACE2抑制剂，可用作治疗和/或预防治疗阿尔茨海默病、糖尿病，特别是2型糖尿病，以及其他代谢性疾病的药物。
• 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
  申请人：Hilpert Hans

  公开号：US20130040936A1

  公开（公告）日：2013-02-14

  This invention relates to compounds of the formula wherein and R 1 to R 3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

  本发明涉及公式中的化合物，其中R1至R3如本文所述，或其药用可接受的盐。这些化合物是BACE1和/或BACE2抑制剂，可用作药物治疗和/或预防治疗阿尔茨海默病、糖尿病，特别是2型糖尿病，以及其他代谢性疾病。
• 1,4 OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20140323469A1

  公开（公告）日：2014-10-30

  This invention relates to compounds of the formula wherein and R 1 to R 3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

  本发明涉及以下式子的化合物 其中R1到R3如本文所述，或其药学上可接受的盐。这些化合物是BACE1和/或BACE2抑制剂，可用作药物治疗和/或预防治疗阿尔茨海默病、糖尿病，尤其是2型糖尿病和其他代谢性疾病。
• US8815841B2
  申请人：——

  公开号：US8815841B2

  公开（公告）日：2014-08-26