| 1313869-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1313869-13-4
• 化学式: C₁₀H₉ClO₂
• 分子量: 196.633
• InChiKey: GEUMXACUFZRSHX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 1,5-cis,cis-cyclooctadiene 、 bis(η3-allyl-μ-chloropalladium(II)) 、 溶剂黄146 、 lithium chloride 作用下， 反应 6.0h， 以78%的产率得到4-[(Z)-1,2-dichloroethenyl]-1,2-dimethoxybenzene
  参考文献：
  名称：

  Highly stereoselective synthesis of (Z)-1,2-dihaloalkenes by a Pd-catalyzed hydrohalogenation of alkynyl halides

  摘要：

  一种前所未有的钯催化的炔基卤化物的氢卤化反应已经实现，能够区域和立体选择性合成（Z）-1,2-二卤烯，使用的催化剂为[(烯丙基)PdCl]2，配体为顺,顺-1,5-环辛二烯。该方法的优势通过迭代交叉偶联反应组装三取代的（Z）-烯炔和通过串联的Diels–Alder–芳构化反应组装多功能苯烃得到了很好的体现。

  DOI：

  10.1039/c2cc31553j

文献信息

• Palladium-Catalyzed Coupling of Haloalkynes with Allyl Acetate: A Regio- and Stereoselective Synthesis of (<i>Z</i>)-β-Haloenol Acetates
  作者：Xiaoyi Chen、Dongxu Chen、Zenghui Lu、Lichun Kong、Gangguo Zhu

  DOI：10.1021/jo2005318

  日期：2011.8.5

  Pd-catalyzed coupling of haloalkynes with allyl acetate has been reported, providing a convenient method for the stereoselective synthesis of (Z)-β-haloenol acetates in good yields. The synthetic utility of this method is demonstrated by the formation of functionalized enol acetates via the Suzuki–Miyaura or Sonogashira coupling of the resulting (Z)-β-haloenol acetate products.

  已经报道了钯催化卤代炔烃与乙酸烯丙酯的偶联，为以高收率立体选择性合成（Z）-β-卤代烯醇乙酸酯提供了便利的方法。该方法的合成实用性通过生成的（Z）-β-卤代烯醇乙酸酯产物的Suzuki-Miyaura或Sonogashira偶联形成官能化的烯醇乙酸酯得到证明。
• Synthesis of cis-1,2-dichlorovinylsulfones via Fe-catalyzed regio- and stereoselective addition of sulfonyl chlorides to aromatic chloroalkynes
  作者：Lina Wang、Hui Zhu、Jianwei Che、Yuanfa Yang、Gangguo Zhu

  DOI：10.1016/j.tetlet.2013.12.063

  日期：2014.1

  An iron-catalyzed regio- and stereoselective chlorosulfonylation of aryl chloroalkynes has been described, producing cis-1,2-dichlorovinylsulfones in satisfactory yields with good to excellent stereoselectivity (Z/E up to 95:5). A variety of functional groups such as F, NO2, Cl, Br, OMe, and t-Bu are found to be compatible under the reaction conditions. (C) 2013 Elsevier Ltd. All rights reserved.