(R)-3-hydroxymethyl-2,3,4,5-tetrahydropyridazine | 1256461-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (R)-3-hydroxymethyl-2,3,4,5-tetrahydropyridazine
• 英文别名: [(6R)-1,4,5,6-tetrahydropyridazin-6-yl]methanol
• CAS: 1256461-43-4
• 化学式: C₅H₁₀N₂O
• 分子量: 114.147
• InChiKey: ISCMRMWVOULKFT-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  44.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (R)-3-((tert-butyldiphenylsilyloxy)methyl)-2,3,4,5-tetrahydropyridazine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到(R)-3-hydroxymethyl-2,3,4,5-tetrahydropyridazine
  参考文献：
  名称：

  Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines

  摘要：

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.030

文献信息

• Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines
  作者：Delphine Kalch、Ramzi Ait Youcef、Xavier Moreau、Christine Thomassigny、Christine Greck

  DOI：10.1016/j.tetasy.2010.07.030

  日期：2010.9

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.