(4-Methyl-cyclohex-3-enyl)-methanethiol | 33176-82-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: (4-Methyl-cyclohex-3-enyl)-methanethiol
• 英文别名: (4-Methylcyclohex-3-en-1-yl)methanethiol
• CAS: 33176-82-8
• 化学式: C₈H₁₄S
• 分子量: 142.265
• InChiKey: DSLKJLHXWHQHRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] TRIAZOLES AS OXYTOCIN ANTAGONISTS<br/>[FR] TRIAZOLES UTILISES COMME ANTAGONISTES DE L'OXYTOCINE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2003053437A1

  公开（公告）日：2003-07-03

  The present invention relates to triazole derivatives of formula (I) notably for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such triazole deriva-tives. Said triazoles are useful in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. In particular, the present invention is related to triazole derivatives displaying a substantial modulatory, in particular antagonistic activity, of the oxytocin and/or vasopressin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin and/or vasopressin. The present invention is furthermore related to novel triazole derivatives as well as to methods of their preparation.