8-methoxy-4H-thieno[2',3':3,4]pyrrolo[1,2-a]indol-9-yl benzenesulfonate | 1067249-47-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-methoxy-4H-thieno[2',3':3,4]pyrrolo[1,2-a]indol-9-yl benzenesulfonate
• 英文别名: (5-Methoxy-11-thia-1-azatetracyclo[7.6.0.02,7.010,14]pentadeca-2(7),3,5,8,10(14),12-hexaen-6-yl) benzenesulfonate；(5-methoxy-11-thia-1-azatetracyclo[7.6.0.02,7.010,14]pentadeca-2(7),3,5,8,10(14),12-hexaen-6-yl) benzenesulfonate
• CAS: 1067249-47-1
• 化学式: C₂₀H₁₅NO₄S₂
• 分子量: 397.475
• InChiKey: KEGMCTYJVILDRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  94.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2,2-dibromovinyl)-6-methoxy-3-[(3-thienylmethyl)amino]phenyl benzenesulfonate 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三(2-甲氧基苯基)膦 、 caesium carbonate 、 silver carbonate 作用下， 以 甲苯 为溶剂， 以91%的产率得到8-methoxy-4H-thieno[2',3':3,4]pyrrolo[1,2-a]indol-9-yl benzenesulfonate
  参考文献：
  名称：

  Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics

  摘要：

  Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.

  DOI：

  10.1021/ol801932z

文献信息

• Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics
  作者：Christopher S. Bryan、Mark Lautens

  DOI：10.1021/ol801932z

  日期：2008.10.16

  Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.