7-(Diethylamino)-3-[2-[1-[(2-hydroxy-5-nitrophenyl)methyl]-3,3-dimethylindol-1-ium-2-yl]ethenyl]chromen-2-one | 1402076-43-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(Diethylamino)-3-[2-[1-[(2-hydroxy-5-nitrophenyl)methyl]-3,3-dimethylindol-1-ium-2-yl]ethenyl]chromen-2-one
• CAS: 1402076-43-0
• 化学式: C₃₂H₃₂N₃O₅
• 分子量: 538.623
• InChiKey: WQRUKZKSSHENQB-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  98.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  7-(diethylamino)-3-(2-(6,6-dimethyl-2-nitro-12H-benzo[5,6][1,3]oxazino[3,2-a]indol-5a(6H)-yl)vinyl)-2H-chromen-2-one 在 三氟乙酸 作用下， 生成 7-(Diethylamino)-3-[2-[1-[(2-hydroxy-5-nitrophenyl)methyl]-3,3-dimethylindol-1-ium-2-yl]ethenyl]chromen-2-one
  参考文献：
  名称：

  基于恶嗪助色剂的可切换荧光团的超分辨率成像。

  摘要：

  荧光显微镜的空间分辨率受衍射限制在光波长的一半左右，从而妨碍了对许多重要细胞内过程的观察。最近出现的新技术已经克服了衍射障碍，它利用了在显微镜的空间分辨率内无法分辨或模糊的近距离物体的时间分辨能力。这些技术的关键是利用其独特的分子状态来打开和关闭荧光标记的信号，并在单分子水平上检测和定位这些标记。该基本原理突出了探针的光物理性质的关键作用，以及寻找足够的开关机制的重要性。这里，我们提出了基于包含[1,3]恶嗪作为两种状态的新型分子组装体来实现荧光调制的策略，这是负责该转化的构件。基于最终的荧光转换事件，基于恶嗪的光致变色和卤代变色特性，两种不同的触发事件引起侧基荧光团的大吸收和发射红移。还讨论了实现超出衍射极限的空间分辨率的这些方法的实现。

  DOI：

  10.1111/php.12100

文献信息

• Synthesis, acid properties and catalysis by niobium oxide nanostructured materials
  作者：M. Luisa Marin、Geniece L. Hallett-Tapley、Stefania Impellizzeri、Chiara Fasciani、Sabrina Simoncelli、José Carlos Netto-Ferreira、Juan C. Scaiano

  DOI：10.1039/c4cy00238e

  日期：——

  Several forms of niobium oxide were prepared, including nanostructured mesoporous materials, and their acidity properties were comprehensively investigated and compared with commercially available materials. The composites were characterized by a variety of techniques, including XRD, TEM, N2 adsorption and Hammett acid indicator studies. The acidity of the niobium oxide derivatives was also investigated by the ability of the materials to successfully promote the halochromic ring-opening of an oxazine-coumarin probe that was specifically designed for use in fluorescence imaging studies. The ring-opening reaction was easily monitored using UV-visible, fluorescence and NMR spectroscopy. Single molecule microscopy was employed to gain a more in-depth understanding of the niobium oxide acid catalysis pathway. Using this technique, the rate of niobium oxide mediated protonation was estimated to be 1.8 × 10−13 mol m−2 s−1. Single molecule analysis was also used to obtain a detailed map of Brønsted acid sites on the niobium oxide surface. The active sites, located by multiple blinking events, do not seem to be localized on any area of the material, but rather randomly distributed throughout the solid state surface. As the reaction proceeds, the sites with the highest acidity and accessibility are gradually consumed, making the next tier of acid sites available for reaction. The phenomenon was more closely characterized by using time lapsed reactivity maps.

  制备了几种形式的氧化铌，包括纳米结构介孔材料，并对其酸性进行了全面研究，并与市售材料进行了比较。通过 XRD、TEM、N2 吸附和 Hammett 酸指示剂研究等多种技术对复合材料进行了表征。氧化铌衍生物的酸性还通过这些材料成功促进专门设计用于荧光成像研究的恶嗪-香豆素探针的卤代开环反应的能力进行了研究。利用紫外可见光、荧光和核磁共振光谱可以轻松监测开环反应。为了更深入地了解氧化铌的酸催化途径，我们采用了单分子显微镜技术。利用这一技术，氧化铌介导的质子化速率估计为 1.8 × 10-13 mol m-2 s-1。单分子分析还用于获得氧化铌表面布氏酸位点的详细图谱。通过多次闪烁事件定位的活性位点似乎并不集中在材料的任何区域，而是随机分布在整个固态表面。随着反应的进行，酸度和可及性最高的位点逐渐被消耗掉，从而使下一层酸性位点可用于反应。通过使用时滞反应图可以更准确地描述这种现象。
• Photochemical synthesis and characterization of novel samarium oxide nanoparticles: toward a heterogeneous Brønsted acid catalyst
  作者：Gregory K. Hodgson、Stefania Impellizzeri、Geniece L. Hallett-Tapley、Juan C. Scaiano

  DOI：10.1039/c4ra14841j

  日期：——

  Samarium oxide nanoparticles (Sm2O3NP) were prepared photochemically for the first time. Characterization shows spherical, polydisperse Sm2O3NP stabilized by 4-HEBA, a substituted benzoic acid. The Sm2O3NP also possess Brønsted acidity. This new material may prove to be a potent heterogeneous acid catalyst.

  首次光化学制备了氧化mar纳米颗粒（Sm 2 O 3 NP）。表征显示通过4-HEBA（一种取代的苯甲酸）稳定的球形多分散Sm 2 O 3 NP。Sm 2 O 3 NP也具有布朗斯台德酸度。这种新材料可能被证明是有效的多相酸催化剂。