2-(2-hydroxy-3-morpholinopropyl)-5-methyl-4-isoxazolin-3-one | 78754-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(2-hydroxy-3-morpholinopropyl)-5-methyl-4-isoxazolin-3-one
• 英文别名: 2-(2-Hydroxy-3-morpholin-4-ylpropyl)-5-methyl-1,2-oxazol-3-one
• CAS: 78754-18-4
• 化学式: C₁₁H₁₈N₂O₄
• 分子量: 242.275
• InChiKey: FNPYEXRPNZWWRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  62.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Centrally-acting muscle relaxants
  申请人：Sankyo Company Limited

  公开号：EP0273744A2

  公开（公告）日：1988-07-06

  Isoxazolin-3-one derivatives represented by the general formula [in which, R¹ represents a hydrogen atom or a halogen atom; R² represents a lower alkyl group, an aryl group or a heterocyclic group; or R¹ and R², together with the adjacent carbon atoms, form a hydrocarbon ring; R³ represents a hydrogen atom or a lower alkyl group, R⁴ represents a lower alkyl group; or R³ and R⁴, together with the adjacent nitrogen atom, may form an alicyclic amino group], and their pharmaceutically acceptable acid addition salts are useful as centrally-­acting muscle relaxants.

  由通式代表的异噁唑啉-3-酮衍生物 [其中，R¹代表氢原子或卤素原子；R²代表低级烷基、芳基或杂环基团；或者 R¹ 和 R² 与相邻碳原子一起形成一个烃环；R³ 代表氢原子或低级烷基，R⁴ 代表低级烷基；或 R³ 和 R⁴ 与相邻的氮原子一起可形成脂环族氨基]，它们的药学上可接受的酸加成盐可用作中枢作用的肌肉松弛剂。
• Use of isoxazolinones as cerebro-active drugs
  申请人：Sankyo Company Limited

  公开号：EP0334674A2

  公开（公告）日：1989-09-27

  Isoxazolin-3-one derivatives of formula (I): [in which: R¹ is hydrogen or halogen; R² is C₁ - C₄ alkyl, optionally substituted phenyl or heterocyclic; or R¹ and R² together form a hydrocarbon ring; R³ is hydrogen or C₁ - C₄ alkyl; and R⁴ is C₁ - C₄ alkyl; or R³ and R⁴, together with the adjacent nitrogen, form a cycloaliphatic amino group] and pharmacoligically acceptable acid addition salts thereof have been found to have a direct effect on the cerebral circulation and/or metabolism, and they can be used in the treatment of cerebrovascular disorders.

  式(I)的异噁唑啉-3-酮衍生物： 其中R¹ 为氢或卤素；R² 为 C₁ - C₄ 烷基、任选取代的苯基或杂环；或 R¹ 和 R² 共同形成一个烃环；R³ 为氢或 C₁ - C₄ 烷基；R⁴ 为 C₁ - C₄ 烷基；或 R³ 和 R⁴ 与邻近的氮一起形成环脂族氨基]及其药理上可接受的酸加成盐已被发现对脑循环和/或新陈代谢有直接作用，可用于治疗脑血管疾病。
• US5321037A
  申请人：——

  公开号：US5321037A

  公开（公告）日：1994-06-14