1-(3-amino-3-methyl-butyl)-spiro(cyclopropyl-1,4'-2H-3',1'-benzoxazin)-2'-one | 906648-85-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 1-(3-amino-3-methyl-butyl)-spiro(cyclopropyl-1,4'-2H-3',1'-benzoxazin)-2'-one
• 英文别名: 1-(3-Amino-3-methylbutyl)spiro[3,1-benzoxazine-4,1'-cyclopropane]-2-one
• CAS: 906648-85-9
• 化学式: C₁₅H₂₀N₂O₂
• 分子量: 260.336
• InChiKey: VKBIDFANBFMDCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES
  申请人：Konetzki Ingo

  公开号：US20080051392A1

  公开（公告）日：2008-02-28

  The present invention relates to new pharmaceutical combinations which contain in addition to one or more, preferably one compound of general formula 1 wherein the groups R 1 , R 2 and R 3 may have the meanings given in the claims and specification, at least one further active substance 2, processes for preparing them and their use as medicaments.

  本发明涉及包含除了一个或多个一般式1的化合物之外，至少一个进一步的活性物质2的新药物组合，其中R1、R2和R3基团可能具有权利要求和说明书中给定的含义，以及其制备方法和作为药物的用途。
• ENANTIOMERICALLY PURE BETA AGONISTS, MANUFACTURING AND USE THEREOF
  申请人：KONETZKI Ingo

  公开号：US20080070909A1

  公开（公告）日：2008-03-20

  The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups R 1 , R 2 , R 3 , m and Y m− may have the meanings given in the claims and specification, processes for preparing them and their use as medicaments, particularly as medicaments for the treatment of respiratory complaints.

  本发明涉及具有公式1的立体纯化合物，其中R1、R2、R3、m和Ym−可以具有如权利要求和说明书中所给出的含义，以及用于制备它们的方法以及它们作为药物的使用，尤其是作为治疗呼吸系统疾病的药物。
• AEROSOL FORMULATION FOR THE INHALATION OF BETA AGONISTS
  申请人：Nowak Michael

  公开号：US20080053430A1

  公开（公告）日：2008-03-06

  The present invention relates to a propellant-free aerosol formulation which contains one or more compounds of general formula 1 wherein the groups R 1 , R 2 , R 3 and X − may have the meanings indicated in the claims and in the specification, for inhalation.

  本发明涉及一种不含推进剂的气雾剂配方，其包含一个或多个通式1中所示的化合物，其中基团R1、R2、R3和X-可以具有在权利要求书和说明书中指示的含义，用于吸入。
• NEW PHARMACEUTICALLY-ACTIVE COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISEASES
  申请人：KONETZKI Ingo

  公开号：US20090105236A1

  公开（公告）日：2009-04-23

  The present invention relates to the use of the compounds of general formula 1 wherein the groups R 1 , R 2 and R 3 may have the meanings specified in the claims and in the description, for preparing a pharmaceutical composition for the treatment of respiratory complaints, as well as new compounds of formula 1 , processes for preparing them, and pharmaceutical formulations containing them.

  本发明涉及使用通式1中的化合物，其中基团R1、R2和R3可以具有在权利要求书和说明书中指定的含义，用于制备用于治疗呼吸道疾病的药物组合物，以及通式1的新化合物，制备它们的过程，以及含有它们的药物配方。
• New Pharmaceutically-Active Compounds for the Treatment of Respiratory Diseases
  申请人：KONETZKI Ingo

  公开号：US20110053926A1

  公开（公告）日：2011-03-03

  The present invention relates to the use of the compounds of general formula 1 wherein the groups R 1 , R 2 and R 3 may have the meanings specified in the claims and in the description, for preparing a pharmaceutical composition for the treatment of respiratory complaints, as well as new compounds of formula 1, processes for preparing them, and pharmaceutical formulations containing them.

  本发明涉及使用一般式1中的化合物，其中基团R1、R2和R3可以具有在权利要求和说明书中指定的含义，用于制备用于治疗呼吸道疾病的药物组成物，以及公式1的新化合物、制备它们的方法和含有它们的药物配方。