(3S,4S,5R,6R)-3,4,5,6,7-Pentahydroxy-1-phenyl-heptan-2-one | 50721-25-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (3S,4S,5R,6R)-3,4,5,6,7-Pentahydroxy-1-phenyl-heptan-2-one
• 英文别名: Benzyl mannose；(3S,4S,5R,6R)-3,4,5,6,7-pentahydroxy-1-phenylheptan-2-one
• CAS: 50721-25-0
• 化学式: C₁₃H₁₈O₆
• 分子量: 270.282
• InChiKey: RRVAKISBQSPFQT-FDYHWXHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Antidiabetic alpha-substituted phosphonates
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0354322A2

  公开（公告）日：1990-02-14

  Alpha-substituted phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, there­by lowering glucose levels in mammals. These alpha-­substituted phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the syn­thesis of the alpha-substituted phosphonates are also disclosed.

  已公开的α-取代膦酸盐可刺激果糖-1,6-二磷酸酶，抑制6-磷酸果糖-1-激酶，从而降低哺乳动物体内的葡萄糖水平。因此，这些α-取代膦酸盐可用于治疗高血糖和/或糖尿病。还公开了合成α-取代膦酸盐的工艺。
• Antidiabetic phosphates
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0354323A2

  公开（公告）日：1990-02-14

  Phosphates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the en­zyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These phosphates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphates are also disclosed.

  已公开的磷酸盐可刺激果糖-1,6-二磷酸酶，抑制 6-磷酸果糖-1-激酶，从而降低哺乳动物体内的葡萄糖水平。因此，这些磷酸盐可用于治疗高血糖和/或糖尿病。此外，还公开了这些磷酸盐的合成工艺。
• Antidiabetic phosphonates
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0372157A1

  公开（公告）日：1990-06-13

  Phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, therey lowering glu­cose levels in mammals. These phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphonates are also dis­closed.

  已公开的膦酸盐可刺激果糖-1,6-二磷酸酶并抑制 6-磷酸果糖-1-激酶，从而降低哺乳动物体内的葡萄糖水平。因此，这些膦酸盐可用于治疗高血糖和/或糖尿病。此外，还公开了膦酸盐的合成工艺。