6-(2-chloro-6-fluorophenyl)-8-ethoxy-2-(4-morpholinophenyl)aminopyrido[2,3-d]pyrimidin-7-one | 1021303-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 6-(2-chloro-6-fluorophenyl)-8-ethoxy-2-(4-morpholinophenyl)aminopyrido[2,3-d]pyrimidin-7-one
• 英文别名: 6-(2-Chloro-6-fluorophenyl)-8-ethoxy-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one
• CAS: 1021303-98-9
• 化学式: C₂₅H₂₃ClFN₅O₃
• 分子量: 495.941
• InChiKey: WBPICHVWOJKOGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• PYRIDO [2,3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：Murthi Krisna

  公开号：US20110201594A1

  公开（公告）日：2011-08-18

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• US8518958B2
  申请人：——

  公开号：US8518958B2

  公开（公告）日：2013-08-27