(R)-6-cyclohexyl-N-hydroxy-3-(3-(morpholine-4-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide | 348624-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (R)-6-cyclohexyl-N-hydroxy-3-(3-(morpholine-4-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide
• 英文别名: (3R)-6-cyclohexyl-N-hydroxy-3-[3-(morpholine-4-carbonyl)-1,2,4-oxadiazol-5-yl]hexanamide
• CAS: 348624-78-2
• 化学式: C₁₉H₃₀N₄O₅
• 分子量: 394.471
• InChiKey: HLMFJGVJQBEIED-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 甲醇 作用下， 生成 (R)-6-cyclohexyl-N-hydroxy-3-(3-(morpholine-4-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide
  参考文献：
  名称：

  Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: Design, synthesis, and evaluation as topically applied, dermal anti-scarring agents

  摘要：

  Succinyl hydroxamates 1 and 2 are disclosed as novel series of potent and selective inhibitors of procollagen C-proteinase (PCP) which may have potential as anti-fibrotic agents. Carboxamide 7 demonstrated good PCP inhibition and had excellent selectivity over MMPs involved in wound healing. In addition, 7 was effective in a cell-based model of collagen deposition (fibroplasia model) and was very effective at penetrating human skin in vitro. Compound 7 (UK-383,367) was selected as a candidate for evaluation in clinical studies as a topically applied, dermal anti-scarring agent. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.036