eicosa-5t,8t,11t,14t,17t-pentaen-1-ol | 99521-73-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: eicosa-5t,8t,11t,14t,17t-pentaen-1-ol
• 英文别名: 5,8,11,14,17-Eicosapentaen-1-ol, (5Z,8Z,11Z,14Z,17Z)-；(5E,8E,11E,14E,17E)-icosa-5,8,11,14,17-pentaen-1-ol
• CAS: 99521-73-0
• 化学式: C₂₀H₃₂O
• 分子量: 288.473
• InChiKey: LUDPTMYCBZDPEZ-RCHUDCCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  eicosa-5t,8t,11t,14t,17t-pentaen-1-ol 生成 Δ⁵,8,11,14,17-Eicosapentaenyljodid
  参考文献：
  名称：

  Untersuchungen über den Stoffwechsel der Polyenfettsäuren bei der Ratte

  摘要：

  DOI：

  10.1515/bchm2.1960.320.1.218

文献信息

• [EN] LIPID COMPOSITIONS CONTAINING DERIVATIVES OF EPA AND DHA AN THEIR USE THEREOF<br/>[FR] COMPOSITIONS LIPIDIQUES RENFERMANT DES DÉRIVÉS D'EPA ET DE DHA ET LEUR UTILISATION
  申请人：PRONOVA BIOPHARMA NORGE AS

  公开号：WO2009134147A1

  公开（公告）日：2009-11-05

  The present invention relates to a lipid composition comprising at least pro-drugs of omega-3 polyunsaturated alcohols, which pro-drugs of omega-3 polyunsaturated alcohols comprise at least one pro-drug of (all-Z) 5,8,11,14,17-eicosapentaen-1-ol, and at least one pro-drug of (all-Z)-4,7,10,13,16,19-docosahexaen-1-ol and their use as a pharmaceutical, in particular for the treatment of elevated triglyceride levels. The invention also relates to methods for the preparation of these pro-drugs from marine oils.

  本发明涉及一种脂质组合物，其中至少包括ω-3多不饱和醇的前药，这些ω-3多不饱和醇的前药至少包括（全反式）5,8,11,14,17-二十碳五烯醇的前药和（全反式）4,7,10,13,16,19-二十二碳六烯醇的前药，以及它们在制药学中的应用，特别是用于治疗高三酰甘油血症。本发明还涉及从海洋油中制备这些前药的方法。
• Cytoprotective Compounds
  申请人：——

  公开号：US20020002296A1

  公开（公告）日：2002-01-03

  The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.

  本发明提供了用于保护细胞免受固有膜溶解、氧化和/或有害物质入侵所致损伤的组合物和方法。更具体地说，本发明提供了用于治疗或预防磷脂酶介导的损伤、氧化引起的损伤和炎症的组合物和方法。在非常具体的意义上，本发明提供了这些组合物的制备方法，这些组合物是磷脂酶抑制剂。
• Cytoprotective compounds
  申请人：——

  公开号：US20030078417A1

  公开（公告）日：2003-04-24

  The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.

  本发明提供了用于保护细胞免受内在膜溶解、氧化和/或破坏性因子侵袭的组合物和方法。更具体地说，本发明提供了用于治疗或预防磷脂酶介导的损伤、氧化损伤和炎症的组合物和方法。在非常具体的意义上，本发明提供了抑制磷脂酶的组合物及制备这些组合物的方法。
• CYTOPROTECTIVE COMPOUNDS
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：EP0898559A2

  公开（公告）日：1999-03-03
• JPH02131418A
  申请人：——

  公开号：JPH02131418A

  公开（公告）日：1990-05-21