| 880493-16-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 880493-16-3
• 化学式: C₁₉H₂₃N₃O₇
• 分子量: 405.408
• InChiKey: VVSBTOXBEVKOMS-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  Nocardimicin B 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 22.0h， 以0.3 mg的产率得到
  参考文献：
  名称：

  Nocardimicins A, B, C, D, E, and F, Siderophores with Muscarinic M3 Receptor Inhibiting Activity from Nocardia sp. TP-A0674

  摘要：

  In the screening for muscarinic M3 receptor binding inhibitors from microbial secondary metabolites, the extract of Nocardia sp. TP-A0674 was found to be highly active. Bioassay-guided fractionation of it led to the isolation of six new siderophores, nocardimicins A (1), B (2), C (3), D (4), E (5), and F (6), as active principles. Their chemical structures were determined by spectroscopic and degradation analysis. Of these congeners, nocardimicin B (2) inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor most potently with a K-i value of 0.13 mu M. Compound 2 showed more selective activity to M3 and M4 receptors than other subtypes.

  DOI：

  10.1021/np050091j