4-(3-硝基苯基)苯甲酸乙酯 | 108620-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(3-硝基苯基)苯甲酸乙酯
• 英文名称: ethyl 3'-amino-[1,1'-biphenyl]-4-carboxylate
• 英文别名: 3'-nitro-biphenyl-4-carboxylic acid ethyl ester；3'-Nitro-biphenyl-4-carbonsaeure-aethylester；ethyl 3'-nitrobiphenyl-4-carboxylate；Ethyl 4-(3-nitrophenyl)benzoate
• CAS: 108620-55-9
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: WCZWAMAIMGEQNT-UHFFFAOYSA-N

物化性质

• 熔点：
  113.7-114.4 °C(Solv: ethanol (64-17-5))
• 沸点：
  420.1±38.0 °C(Predicted)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  4-(3-硝基苯基)苯甲酸乙酯 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 生成 3'-amino-biphenyl-4-carboxylic acid ethyl ester
  参考文献：
  名称：

  Conformational analogues of Oxamflatin as histone deacetylase inhibitors

  摘要：

  我们合成了羟肟酸 Oxamflatin 1 的构象类似物--化合物 3a、3b 和 4，以评估改变连接部分对组蛋白去乙酰化酶抑制作用的影响。初步测试表明，用每种类似物处理白血病细胞，都能显著抑制组蛋白去乙酰化酶，减少细胞的生长和增殖。

  DOI：

  10.1039/b608213k
• 作为产物：
  描述：

  对碘苯甲酸乙酯 、 3-硝基苯硼酸 在 potassium carbonate 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以89%的产率得到4-(3-硝基苯基)苯甲酸乙酯
  参考文献：
  名称：

  Suzuki–Miyaura reaction catalyzed by graphene oxide supported palladium nanoparticles

  摘要：

  Pd supported on polyamine modified graphene oxide (GO-NH2-Pd2+) was fabricated for the first time. The prepared catalyst was characterized by transmission electron microscopy, X-ray diffraction spectroscopy, X-ray photoelectron spectroscopy and infrared spectroscopy. The catalytic activity of the prepared catalyst was investigated by employing Suzuki-Miyaura coupling reaction as a model reaction. A series of biphenyl compounds were synthesized through the Suzuki-Miyaura reaction using GO-NH2-Pd2+ as catalyst. The yields of the products were in the range from 71% to 95%. The catalyst can be readily recovered and reused at least 10 consecutive cycles without significant loss its catalytic activity. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2013.06.006

文献信息

• [EN] METHOD OF TREATMENT AND DEVICE<br/>[FR] MÉTHODE DE TRAITEMENT ET DISPOSITIF
  申请人：UNIV MONASH

  公开号：WO2020142809A1

  公开（公告）日：2020-07-16

  A method and an angioplasty balloon catheter used in a method of preventing or minimizing incidence of neointimal hyperplasia (NIH) in a blood vessel of an animal following angioplasty treatment. The method comprising locating the angioplasty balloon catheter at a vessel site where angioplasty treatment is desired, wherein a balloon component of the catheter is at least partially coated on an external surface thereof with a photo-labile drug / linker conjugate of Formula I; wherein the balloon is inflated at the site to initiate release of the drug / linker conjugate to vessel wall at the site and an optical fiber light diffuser, connected by optical fiber to a source of UV light at a wavelength of from about 350 nm to about 380 nm, is located within the balloon to emit said UV light, wherein UV light emission is of suitable power and for sufficient duration to cleave the drug / linker conjugate and activate an effective amount of the drug of Formula II to prevent or minimize NIH following the angioplasty treatment at the site.

  本发明涉及一种方法和一种用于预防或最小化在动物的血管内进行成形术治疗后发生新内膜增生（NIH）的血管成形术球囊导管。该方法包括将血管成形术球囊导管定位在需要进行血管成形术治疗的血管部位，其中导管的球囊组件至少部分地涂覆有配方I的光敏药物/连接剂共轭物的外表面；在该部位充气球囊以启动在该部位向血管壁释放药物/连接剂共轭物，并且在球囊内放置光纤光扩散器，通过光纤连接到波长为约350nm至约380nm的紫外线光源，其中紫外线光发射具有足够的功率和足够长的持续时间，以断裂药物/连接剂共轭物并激活配方II的有效量，以预防或最小化在该部位进行血管成形术治疗后的NIH。
• Novel bicyclic hydroxamates as inhibitors of histone deacetylase
  申请人：Leahy M Ellen

  公开号：US20060058553A1

  公开（公告）日：2006-03-16

  The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed

  本发明涉及某些双环羟肟衍生物，它们是组蛋白去乙酰化酶的抑制剂，因此可以用于治疗与组蛋白去乙酰化酶活性相关的疾病。本发明还公开了制备这些化合物的制药组合物和过程。
• The Hydrolysis of Substituted Ethyl p-Biphenylcarboxylates
  作者：Ernst Berliner、Liang Huang Liu

  DOI：10.1021/ja01106a042

  日期：1953.5
• Makarowa et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 1452,1457; engl. Ausg. S. 1399, 1404
  作者：Makarowa et al.

  DOI：——

  日期：——
• Palladium-Catalyzed Cross-Coupling Reactions with Aryl Nonaflates:  A Practical Alternative to Aryl Triflates
  作者：Mario Rottländer、Paul Knochel

  DOI：10.1021/jo971636k

  日期：1998.1.1