propan-2-yl N-[N-[(2S)-2-[5-(3,5-dimethylphenyl)-2-(2-methyl-1-oxo-1-pyrrolidin-1-ylpropan-2-yl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-C-(3-pyridin-4-ylpyrrolidin-1-yl)carbonimidoyl]carbamate | 667940-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: propan-2-yl N-[N-[(2S)-2-[5-(3,5-dimethylphenyl)-2-(2-methyl-1-oxo-1-pyrrolidin-1-ylpropan-2-yl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-C-(3-pyridin-4-ylpyrrolidin-1-yl)carbonimidoyl]carbamate
• CAS: 667940-40-1
• 化学式: C₃₉H₅₀N₆O₃S
• 分子量: 682.93
• InChiKey: XBOVNMVSGSJRHU-SCBLGKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  49
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• THIENO-PYRROLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE
  申请人：AstraZeneca AB

  公开号：EP1532154B1

  公开（公告）日：2008-01-16
• Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
  申请人：Arnould Jean Claude

  公开号：US20060004053A1

  公开（公告）日：2006-01-05

  The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R 1 , R 2 , R 4 , R 5 , R 6 , R 6a , R 7 , R 8 , A and B are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
• US7317010B2
  申请人：——

  公开号：US7317010B2

  公开（公告）日：2008-01-08