N-methyl-N-propyl-isobutyramide | 101258-95-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methyl-N-propyl-isobutyramide
• 英文别名: Isobuttersaeure-(methyl-propyl-amid)；N-Methyl-N-propyl-isobutyramid；N,2-dimethyl-N-propylpropanamide
• CAS: 101258-95-1
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: YJFZIJOSKMUUMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基正丙胺 、 异丁酰氯 生成 N-methyl-N-propyl-isobutyramide
  参考文献：
  名称：

  The Preparation and Properties of Oxaziranes

  摘要：

  DOI：

  10.1021/ja01578a043

文献信息

• TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20160376283A1

  公开（公告）日：2016-12-29

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

  本发明涉及式I化合物及其药用可接受的组合物，用作TBK/IKKε抑制剂。
• Purinone Derivatives as Tyrosine Kinase Inhibitors
  申请人：Principia Biopharma Inc.

  公开号：US20140142099A1

  公开（公告）日：2014-05-22

  The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as autoimmune diseases, cancer and inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

  本公开提供了一些酪氨酸激酶抑制剂及其药用盐，特别是BLK、BMX、EGFR、HER2、HER4、ITK、TEC、BTK和TXK，因此适用于治疗通过抑制酪氨酸激酶可治疗的疾病，如自身免疫疾病、癌症和炎症性疾病。还提供了含有这些化合物和药用盐的药物组合物，以及制备这些化合物和药用盐的方法。
• PRO-SUBSTRATES FOR LIVE CELL APPLICATIONS
  申请人：PROMEGA CORPORATION

  公开号：US20150212078A1

  公开（公告）日：2015-07-30

  Provided are pro-substrates useful in assays of living cells. The pro-substrates can be used to detect the presence or absence of enzymes, such as luciferase, in living cells. The pro-substrates can be coelenterazine derivatives or analogues.

  提供了在活细胞测定中有用的前体底物。这些前体底物可用于检测活细胞中酶的存在或缺失，如荧光素酶。这些前体底物可以是海葵素衍生物或类似物。
• ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS
  申请人：Attardo Giorgio

  公开号：US20090275538A1

  公开（公告）日：2009-11-05

  The present invention relates to Arylmethylidene heterocycles, compositions comprising an Arylmethylidene heterocycle, and methods useful for treating or preventing pain comprising administering an effective amount of an Arylmethylidene heterocycle. The compounds, compositions, and methods of the invention are also useful for treating or preventing inflammation.

  本发明涉及芳基甲基亚胺杂环，包含芳基甲基亚胺杂环的组合物，以及用于治疗或预防疼痛的方法，其中包括给予有效量的芳基甲基亚胺杂环。本发明的化合物、组合物和方法也适用于治疗或预防炎症。
• Method of producing polyimide resin, method of producing polyimide coating, method of producing polyamic acid solution, polyimide coating, and polyamic acid solution
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：EP2907838A1

  公开（公告）日：2015-08-19

  Provided is a method of producing a polyimide resin that produces a polyimide resin excellent in heat resistance and mechanical properties and having a low dielectric constant even when heat-treated at a lower temperature. The method of producing a polyimide resin according to the present invention includes heating at from 120°C to 350°C a polyamic acid resulting from the reaction of a tetracarboxylic acid dianhydride component and a diamine component in a solvent comprising at least a compound (A) represented by the general formula (1), in which R1 represents a hydrogen atom or a hydroxyl group, R2 and R3 independently represent a hydrogen atom or a C1 to C3 alkyl group, and R4 and R5 independently represent a C1 to C3 alkyl group.

  本发明提供了一种生产聚酰亚胺树脂的方法，该方法可生产出耐热性和机械性能优异的聚酰亚胺树脂，即使在较低温度下进行热处理，其介电常数也很低。根据本发明生产聚酰亚胺树脂的方法包括在 120°C 至 350°C 的温度下加热由四羧酸二酐组分和二胺组分在溶剂中反应生成的聚酰胺，该溶剂至少包含通式（1）代表的化合物（A），其中 R1 代表氢原子或羟基，R2 和 R3 独立地代表氢原子或 C1 至 C3 烷基，R4 和 R5 独立地代表 C1 至 C3 烷基。