2-(5-Methoxypyridin-2-yl)-1-methylbenzimidazole | 1339934-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(5-Methoxypyridin-2-yl)-1-methylbenzimidazole
• 英文别名: 2-(5-methoxypyridin-2-yl)-1-methylbenzimidazole
• CAS: 1339934-32-5
• 化学式: C₁₄H₁₃N₃O
• 分子量: 239.277
• InChiKey: IKAQXZFCAJHQBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(5-hydroxypyridin-2-yl)-1H-benzo[d]imidazole 、 碘甲烷 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 37.0h， 以70%的产率得到2-(5-Methoxypyridin-2-yl)-1-methylbenzimidazole
  参考文献：
  名称：

  CuI-catalyzed hydroxylation of aryl bromides under the assistance of 5-bromo-2-(1H-imidazol-2-yl)pyridine and related ligands

  摘要：

  A number of substituted 2-pyridin-2-yl-1H-benzoimidazoles and 2-(1H-imidazol-2-yl)pyridines were screened for promoting CuI-catalyzed hydroxylation of aryl bromides, which led to the discovery of the combination of Cut and 5-bromo-2-(1H-imidazol-2-yl)pyridine as an effective catalytic system for this transformation. Both electron-rich and electronic-deficient aryl bromides could be converted into the corresponding substituted phenols in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.059

文献信息

• CuI-catalyzed hydroxylation of aryl bromides under the assistance of 5-bromo-2-(1H-imidazol-2-yl)pyridine and related ligands
  作者：Jianhuan Jia、Chenglin Jiang、Xiaojing Zhang、Yongwen Jiang、Dawei Ma

  DOI：10.1016/j.tetlet.2011.08.059

  日期：2011.10

  A number of substituted 2-pyridin-2-yl-1H-benzoimidazoles and 2-(1H-imidazol-2-yl)pyridines were screened for promoting CuI-catalyzed hydroxylation of aryl bromides, which led to the discovery of the combination of Cut and 5-bromo-2-(1H-imidazol-2-yl)pyridine as an effective catalytic system for this transformation. Both electron-rich and electronic-deficient aryl bromides could be converted into the corresponding substituted phenols in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.