5-(2-Acetylamino-2-carboxy-ethylsulfanyl)-2-[2,2-difluoro-2-(4'-methoxy-biphenyl-4-yl)-ethyl]-4-hydroxy-pentanoic acid | 362626-37-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(2-Acetylamino-2-carboxy-ethylsulfanyl)-2-[2,2-difluoro-2-(4'-methoxy-biphenyl-4-yl)-ethyl]-4-hydroxy-pentanoic acid
• 英文别名: 5-(2-Acetamido-2-carboxyethyl)sulfanyl-2-[2,2-difluoro-2-[4-(4-methoxyphenyl)phenyl]ethyl]-4-hydroxypentanoic acid
• CAS: 362626-37-7
• 化学式: C₂₅H₂₉F₂NO₇S
• 分子量: 525.571
• InChiKey: YFAPMUMRMKYXAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  159
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Difluorobutyric acid metalloprotease inhibitors
  申请人：The Procter & Gamble Company

  公开号：US20030139453A1

  公开（公告）日：2003-07-24

  Compounds according to the following Formula (I): 1 are effective in treating conditions characterized by the excess metalloprotease activity.

  按照以下公式（I）的化合物在治疗过度金属蛋白酶活性所表现的疾病方面具有有效性。
• DIFLUOROBUTYRIC ACID DERIVATIVES AND THEIR USE AS METALLOPROTEASE INHIBITORS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1265865A2

  公开（公告）日：2002-12-18
• [EN] DIFLUOROBUTYRIC ACID METALLOPROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE METALLOPROTEASES D'ACIDE DIFLUOROBUTYRIQUE
  申请人：PROCTER & GAMBLE

  公开号：WO2001070693A2

  公开（公告）日：2001-09-27

  Compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess metalloprotease activity. In particular, the compounds have a structure according to the following Formula (I): where A, G, R?1, R2, R3¿, X, Y and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula I, pharmaceutically-acceptable salts, biohydrolyzable, esters thereof and conjugates thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions. This invention also includes intermediates useful for the synthesis of the compounds of Formula (I).