4-amino-2-butyl-α,α-dimethyl-1H-imidazo[4,5-c][1,5]naphthyridine-1-ethanol | 227319-08-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-amino-2-butyl-α,α-dimethyl-1H-imidazo[4,5-c][1,5]naphthyridine-1-ethanol
• 英文别名: 1-(4-Amino-2-butylimidazo[4,5-c][1,5]naphthyridin-1-yl)-2-methylpropan-2-ol
• CAS: 227319-08-6
• 化学式: C₁₇H₂₃N₅O
• 分子量: 313.403
• InChiKey: LYUHYTILTNGGRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Pharmaceutical formulation comprising an immune response modifier
  申请人：3M Innovative Properties Company

  公开号：US20030199538A1

  公开（公告）日：2003-10-23

  Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo-quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines; a fatty acid; and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.

  含有免疫应答调节剂（IRM）的制药配方，所述IRM选择自咪唑喹啉胺，咪唑四氢喹啉胺，咪唑吡啶胺，6,7-融合环烷基咪唑吡啶胺，1,2-桥联咪唑喹啉胺，噻唑喹啉胺，噁唑喹啉胺，噻唑吡啶胺，噁唑吡啶胺，咪唑萘啶胺，四氢咪唑萘啶胺和噻唑萘啶胺；脂肪酸；和与脂肪酸混溶的疏水性无极性成分，对治疗皮肤相关疾病有用。提供了新型局部制剂。在一种实施方式中，该局部制剂对于治疗光化性角化症，手术后疤痕，基底细胞癌，特应性皮炎和疣等方面具有优势。
• Intermediates for imidazonaphthyridines
  申请人：Gerster F. John

  公开号：US20080091010A1

  公开（公告）日：2008-04-17

  Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

  Imidazonaphthyridine和tetrahydroimidazonaphthyridine化合物能够诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。这些化合物具有抗病毒和抗肿瘤的特性。本文披露了制备这些化合物及其中间体的方法。
• IMIDAZONAPHTHYRIDINES
  申请人：Lindstrom J. Kyle

  公开号：US20070167481A1

  公开（公告）日：2007-07-19

  Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

  Imidazonaphthyridine和tetrahydroimidazonaphthyridine化合物能够诱导干扰素和肿瘤坏死因子等细胞因子的生物合成。这些化合物具有抗病毒和抗肿瘤的特性。本发明还公开了制备这些化合物和在制备这些化合物中有用的中间体的方法。
• PHARMACEUTICAL FORMULATIONS COMPRISING AN IMMUNE RESPONSE MODIFIER
  申请人：3M Innovative Properties Company

  公开号：EP1450804A1

  公开（公告）日：2004-09-01
• FORMULATIONS CONTAINING AN IMMUNE RESPONSE MODIFIER
  申请人：3M Innovative Properties Company

  公开号：EP1651190B1

  公开（公告）日：2012-09-19