2-(6-methylpyridin-2-yl)-1-[2-(4-(morpholin-4-yl) phenyl)-pyridin-4-yl]-ethanone | 656257-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(6-methylpyridin-2-yl)-1-[2-(4-(morpholin-4-yl) phenyl)-pyridin-4-yl]-ethanone
• 英文别名: 2-(6-Methylpyridin-2-yl)-1-[2-(4-morpholin-4-ylphenyl)pyridin-4-yl]ethanone
• CAS: 656257-76-0
• 化学式: C₂₃H₂₃N₃O₂
• 分子量: 373.455
• InChiKey: AOFXOHXJEPRIHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR<br/>[FR] DERIVES DE PYRAZOLE AGISSANT COMME DES INHIBITEURS DU FACTEUR DE CROISSANCE TRANSFORMANT
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004016606A1

  公开（公告）日：2004-02-26

  The invention relates to novel pyrazole derivatives of formula (I), which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及新型吡唑衍生物，其化学式为(I)，它们是转化生长因子('TGF')-β信号通路的抑制剂，特别是TGF-β I型或激活素样激酶('ALK')-5受体介导的smad2或smad3的磷酸化，以及这些衍生物的制备方法和在医学上的应用，特别是在治疗和预防由该通路介导的疾病状态。
• Compounds
  申请人：Dodic Nerina

  公开号：US20060004051A1

  公开（公告）日：2006-01-05

  The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及一种新型的氨基噻唑衍生物，该衍生物是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是抑制TGF-β类型I或类激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，以及该衍生物的制备方法和在医学上的应用，具体地用于治疗和预防由该通路介导的疾病状态。
• Pyrazole inhibitors of the transforming growth factor
  申请人：Gellibert Jeanne Francoise

  公开号：US20060058329A1

  公开（公告）日：2006-03-16

  The invention relates to novel pyrazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及一种新型吡唑衍生物，其是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是抑制TGF-β类型I或类活素激酶（“ALK”）-5受体对smad2或smad3的磷酸化作用，以及制备这些衍生物的方法和在医学上的应用，具体用于治疗和预防由该通路介导的疾病状态。
• COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1554275A2

  公开（公告）日：2005-07-20
• PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1554268A1

  公开（公告）日：2005-07-20