(R)-ethyl 2,2-dimethyl-3,4-epoxybutanoate | 1228844-75-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-ethyl 2,2-dimethyl-3,4-epoxybutanoate
• 英文别名: ethyl 2-methyl-2-[(2R)-oxiran-2-yl]propanoate
• CAS: 1228844-75-4
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: CUTAMGLIZVLXFD-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3RS) ethyl 3-epoxy-2,2-dimethylacetoacetate 在 C₃₈H₅₇CoN₂O₅ 、 水 作用下， 反应 21.0h， 以47%的产率得到(R)-ethyl 2,2-dimethyl-3,4-epoxybutanoate
  参考文献：
  名称：

  Synthesis of enantiomerically enriched α,α-disubstituted β,γ-epoxy esters using hydrolytic kinetic resolution catalyzed by salenCo(III)

  摘要：

  Novel alpha,alpha-disubstituted epoxy esters were prepared in enantiopure form by hydrolytic kinetic resolution (HKR) of the corresponding racemic mixtures using chiral salenCo(III) as catalyst. The methodology provides a convenient route to enantioenriched beta,gamma-epoxy esters 2a, 2c and 2d. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.03.036

文献信息

• Synthesis of enantiomerically enriched α,α-disubstituted β,γ-epoxy esters using hydrolytic kinetic resolution catalyzed by salenCo(III)
  作者：Ignacio Viera、Eduardo Manta、Lucía González、Graciela Mahler

  DOI：10.1016/j.tetasy.2010.03.036

  日期：2010.3

  Novel alpha,alpha-disubstituted epoxy esters were prepared in enantiopure form by hydrolytic kinetic resolution (HKR) of the corresponding racemic mixtures using chiral salenCo(III) as catalyst. The methodology provides a convenient route to enantioenriched beta,gamma-epoxy esters 2a, 2c and 2d. (C) 2010 Elsevier Ltd. All rights reserved.