glutathione | 117974-03-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glutathione
• 英文别名: GSH；Glutathion；2-Amino-4-[[1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-4-oxobutanoic acid
• CAS: 117974-03-5
• 化学式: C₉H₁₅N₃O₆S
• 分子量: 293.301
• InChiKey: HZSVIWHAEJRBDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  160
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Conjugate of Folate and Antibody Preparation Method and Use Thereof
  申请人：Liu Ying

  公开号：US20130259882A1

  公开（公告）日：2013-10-03

  Anti-tumor conjugates, which consists of foliate or analogues thereof, linkers, an antibodies such as immunoglobulin G. The linker comprises glutathione, cysteamine or cysteine residue, and further comprises N-hydroxysuccinimide. The Conjugates target folate-receptor-positive tumor cells. Also provided are preparation methods and anti-tumor and anti-autoimmune disease uses of the conjugates.
• [EN] CONJUGATE OF FOLATE AND ANTIBODY, PREPARATION METHOD AND USE THEREOF<br/>[FR] CONJUGUÉ DE FOLATES ET D'ANTICORPS, LEUR PROCÉDÉ DE PRÉPARATION ET UTILISATION
  申请人：WUHAN HUAYAO BIOPHARMACEUTICAL CO LTD

  公开号：WO2012062094A1

  公开（公告）日：2012-05-18

  Provided are anti-tumor conjugates, which consist of folate or analogues thereof, linkers, and antibodies such as Immunoglobulin G. The linker comprises glutathione, cysteamine or cysteine residue, and further comprises N-hydroxysuccinimide. The conjugates target folate-receptor-positive tumor cells. Also provided are preparation methods and anti-tumor use of the conjugates.