methyl 6-O-benzoyl-2-O-benzyl-3,4-O-isopropylidene-β-Dgalactopyranoside | 1225206-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 6-O-benzoyl-2-O-benzyl-3,4-O-isopropylidene-β-Dgalactopyranoside
• 英文别名: [(3aS,4R,6R,7R,7aS)-6-methoxy-2,2-dimethyl-7-phenylmethoxy-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yl]methyl benzoate
• CAS: 1225206-91-6
• 化学式: C₂₄H₂₈O₇
• 分子量: 428.482
• InChiKey: ZJOAGCCVRCCIGL-DLBZZEGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  溴甲苯 、 methyl 6-O-benzoyl-3,4-O-isopropylidene-β-D-galactopyranoside 在 silver carbonate 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以65%的产率得到methyl 6-O-benzoyl-2-O-benzyl-3,4-O-isopropylidene-β-Dgalactopyranoside
  参考文献：
  名称：

  A simple, mild, and regioselective method for the benzylation of carbohydrate derivatives promoted by silver carbonate

  摘要：

  A simple, mild, and regioselective method has been developed for the selective benzylation and p-methoxybenzylation of carbohydrate derivatives in high yields using Ag2CO3 as the promoter. Benzylation of base-labile substrates, for which other reported methods are of little use, has been performed in high yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.12.012

文献信息

• A simple, mild, and regioselective method for the benzylation of carbohydrate derivatives promoted by silver carbonate
  作者：Satish Malik、Vaibhav A. Dixit、Prasad V. Bharatam、K.P. Ravindranathan Kartha

  DOI：10.1016/j.carres.2009.12.012

  日期：2010.3

  A simple, mild, and regioselective method has been developed for the selective benzylation and p-methoxybenzylation of carbohydrate derivatives in high yields using Ag2CO3 as the promoter. Benzylation of base-labile substrates, for which other reported methods are of little use, has been performed in high yields. (C) 2010 Elsevier Ltd. All rights reserved.