(Z)-7-{(1R,2R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-5-hydroxy-3-oxo-cyclopentyl}-hept-5-enoic acid | 62145-09-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-7-{(1R,2R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-5-hydroxy-3-oxo-cyclopentyl}-hept-5-enoic acid
• 英文别名: (Z)-7-[(1R,2R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-5-hydroxy-3-oxocyclopentyl]hept-5-enoic acid
• CAS: 62145-09-9
• 化学式: C₂₂H₂₇ClO₆
• 分子量: 422.906
• InChiKey: DHANUGAEEAKTKJ-KYUUVOLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Prostaglandin D derivatives, process for their preparation and compositions containing them
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0097023A2

  公开（公告）日：1983-12-28

  Prostaglandin D derivatives of the formula: wherein R1 is hydrogen or alkyl, R2 is a group of the formula: or wherein R3 is alkyl, R4 is hydrogen or alkyl, R5 is alkyl R6 is a single bond or alkylene, R7 is cycloalkyl, X is ethylene or cis-vinylene, the double bond between C9-C10 is Z, and the double bond between C13-C14 is E, or of the formula: wherein R1, R6 and X are as hereinbefore defined, R8 is alkyl, cycloalkyl, phenyl or phenoxy, the double bonds between C12-C13 and between C14-C15 are E, Z or a mixture thereof, and the double bond between C9-C10 is Z, provided that when R6 represents a single bond, R8 does not represent a substituted or unsubstituted phenoxy group, and cyclodextrin clathrates and non-toxic salts thereof, possess anti-tumour activity.

  式中的前列腺素 D 衍生物： 其中 R1 是氢或烷基，R2 是式中的基团： 或 其中 R3 是烷基，R4 是氢或烷基，R5 是烷基，R6 是单键或亚烷基，R7 是环烷基，X 是乙烯或顺式乙烯，C9-C10 之间的双键是 Z，C13-C14 之间的双键是 E，或 式中： R1、R6 和 X 如前定义，R7 是环烷基，X 是乙烯或顺式乙烯，C9-C10 之间的双键是 Z，C13-C14 之间的双键是 E： 其中 R1、R6 和 X 如前定义，R8 为烷基、环烷基、苯基或苯氧基，C12-C13 之间和 C14-C15 之间的双键为 E、Z 或其混合物，C9-C10 之间的双键为 Z，条件是当 R6 代表单键时，R8 不代表取代或未取代的苯氧基，环糊精凝块及其无毒盐具有抗肿瘤活性。
• COMPOSITIONS AND METHODS TO TREAT EPITHELIAL-RELATED CONDITIONS
  申请人：Lipkin Pamela

  公开号：US20100074857A1

  公开（公告）日：2010-03-25

  The described invention relates to the formulation and delivery of compositions to treat an epithelial-related condition selected from the group consisting of sparse hair growth, short hair growth, thin hair growth, alopecia and hair depigmentation and methods for their use. In some embodiments, the composition contains a first component and a second component wherein the first component is at least one prostaglandin analog and the second component is at least one imidazole analog, such that the at least one imidazole analog improves the efficacy of the at least one prostaglandin analog when delivered to a subject refractory to the effect of the prostaglandin analog alone.
• US4346228A
  申请人：——

  公开号：US4346228A

  公开（公告）日：1982-08-24