butyl (E)-3-(4-trifluoromethyl-2'-methyl[1,1';4',1']terphenyl-4''-yl)acrylate | 1215663-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butyl (E)-3-(4-trifluoromethyl-2'-methyl[1,1';4',1']terphenyl-4''-yl)acrylate
• 英文别名: butyl (E)-3-[3-methyl-4-[4-[4-(trifluoromethyl)phenyl]phenyl]phenyl]prop-2-enoate
• CAS: 1215663-50-5
• 化学式: C₂₇H₂₅F₃O₂
• 分子量: 438.49
• InChiKey: WQRWEEBXTDZOKJ-OMCISZLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  butyl (E)-3-(4'-chloro-2-methylbiphenyl-4-yl)acrylate 、 4-三氟甲基苯硼酸 在 palladium diacetate 、 caesium carbonate 、 1,3-双(2,6-二异丙基苯基)氯化咪唑鎓 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以83%的产率得到butyl (E)-3-(4-trifluoromethyl-2'-methyl[1,1';4',1']terphenyl-4''-yl)acrylate
  参考文献：
  名称：

  Palladium/Imidazolium salt as a versatile catalyst for sequential coupling reactions of aryl dihalides to unsymmetrically substituted arenes

  摘要：

  A simple method for one-pot sequential Heck/Suzuki Coupling reactions of a range of substituted aryl dihalides has been described The Pd(OAc)(2)/imidazolium system catalyzed double coupling reactions proceed Without isolation of the intermediates giving unsymmetrically polysubstituted biphenyls ill good to excel lent yields Further couplings of the resultant products bearing additional C-Cl bonds with substituted arylboronic acids or amines lead to unsymmetrical terphenyls and aminobiphenyl derivatives (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.043

文献信息

• Palladium/Imidazolium salt as a versatile catalyst for sequential coupling reactions of aryl dihalides to unsymmetrically substituted arenes
  作者：Xiaoming Zhang、Weilong Xie、Wanzhi Chen

  DOI：10.1016/j.tet.2009.12.043

  日期：2010.2

  A simple method for one-pot sequential Heck/Suzuki Coupling reactions of a range of substituted aryl dihalides has been described The Pd(OAc)(2)/imidazolium system catalyzed double coupling reactions proceed Without isolation of the intermediates giving unsymmetrically polysubstituted biphenyls ill good to excel lent yields Further couplings of the resultant products bearing additional C-Cl bonds with substituted arylboronic acids or amines lead to unsymmetrical terphenyls and aminobiphenyl derivatives (C) 2009 Elsevier Ltd All rights reserved