1-(propan-2-yl)-1H-pyrazole-4-sulfonamide | 1248262-23-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-(propan-2-yl)-1H-pyrazole-4-sulfonamide
• 英文别名: 1-propan-2-ylpyrazole-4-sulfonamide
• CAS: 1248262-23-8
• 化学式: C₆H₁₁N₃O₂S
• 分子量: 189.24
• InChiKey: OSIPVHZWWAFMCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME
  申请人：The University of Queensland

  公开号：EP3578547A1

  公开（公告）日：2019-12-11

  The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

  本发明提供了某些磺酰脲类及相关化合物，它们在抑制 NLRP3 炎性体活化方面具有优势特性并显示出有用的活性。此类化合物可用于治疗多种疾病，在这些疾病中，炎症过程或更具体地说是 NLRP3 炎症体被认为是一个关键因素。
• Sulfonylureas and related compounds and use of same
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US11130731B2

  公开（公告）日：2021-09-28

  The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

  本发明提供了某些磺酰脲类及相关化合物，它们在抑制 NLRP3 炎性体活化方面具有优势特性并显示出有用的活性。此类化合物可用于治疗多种疾病，在这些疾病中，炎症过程或更具体地说是 NLRP3 炎症体被认为是一个关键因素。
• COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
  申请人：Novartis AG

  公开号：EP3880660A1

  公开（公告）日：2021-09-22
• NLRP3 INHIBITORS
  申请人：INFLAZOME LIMITED

  公开号：US20220106289A1

  公开（公告）日：2022-04-07

  The present application relates to compounds with NLRP 3 inhibitory activity and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present application further relates to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP 3 inhibition.
• [EN] SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME<br/>[FR] SULFONYLURÉES, COMPOSÉS APPARENTÉS, ET LEUR UTILISATION
  申请人：UNIV QUEENSLAND

  公开号：WO2016131098A1

  公开（公告）日：2016-08-25

  ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.