4-Fluorotropacocaine | 172883-97-5

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Fluorotropacocaine
• 英文别名: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 4-fluorobenzoate
• CAS: 172883-97-5；1392492-03-3
• 化学式: C₁₅H₁₈FNO₂
• 分子量: 263.31
• InChiKey: YXDFSLSXLYAAPF-PBWFPOADSA-N

物化性质

• 沸点：
  344.0±32.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Medical fluid, a method of treatment and use of the fluid
  申请人：XVIVO PERFUSION AB

  公开号：US10271540B2

  公开（公告）日：2019-04-30

  A medical fluid for a harvested organ, tissue or part thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analog thereof; noradrenaline; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenaline; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.

  一种用于评估和/或保存摘取的器官、组织或其部分的医用液。该液体包括可卡因或其刺激类似物、去甲肾上腺素和/或肾上腺素。此外，该药液还包括一种抗肿瘤剂，如右旋糖酐；激素，如甲状腺素；三碘酪氨酸；可的松、胰岛素；以及电解质和生理上可接受的介质中基本为生理浓度的营养物质。此外，医用流体还包括浓度不超过 5.0% 的白蛋白和氧载体，如红细胞。其他成分可以是多巴胺、氢化可的松、甲基强的松龙和血管加压剂，如去氨加压素。可卡因、肾上腺素和去甲肾上腺素的浓度各约为 0.010 μM 至 0.100 μM，例如比例为 1:1:1。
• Materials and methods for rapid and sensitive detection of small-molecule targets
  申请人：Xiao Yi

  公开号：US10550395B2

  公开（公告）日：2020-02-04

  The subject invention provides methods, assays and products for detecting small-molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target in a sample comprises providing a sample, contacting the sample with an aptamer-based sensor selective for the small-molecule target, and sensitively and rapidly detecting the small-molecule target in the sample. Specifically, the method utilizes EATR-amplified small-molecule sensors based on cooperative binding split aptamers (CBSAs).

  本发明提供了特别是在临床和现场环境中检测样品中的小分子的方法、检测方法和产品。检测样品中的小分子目标物的方法包括提供样品，将样品与对小分子目标物有选择性的基于适配体的传感器接触，灵敏而快速地检测样品中的小分子目标物。具体地说，该方法利用了基于合作结合分裂拟合物（CBSA）的 EATR 扩增小分子传感器。
• Material and method for colorimetric detection of small-molecule targets
  申请人：Xiao Yi

  公开号：US10725058B2

  公开（公告）日：2020-07-28

  The subject invention provides methods, assays, and products for visual detection of small-molecule targets in a sample in both clinical and field settings within minutes. The subject invention is based on an aptamer sensor that reports the presence of small-molecule target via a sensitive colorimetric signal for naked-eye detection. The aptamer sensor is a CBSAzyme-based sensor having both target-mediated cooperative behavior of the CBSA and peroxidase-mimicking catalytic activity of DNAzyme. The subject invention also provides methods of using the CBSAzyme-based sensor.

  本发明提供了在临床和现场环境中几分钟内目视检测样品中小分子靶标的方法、检测方法和产品。本发明基于一种适配体传感器，该传感器通过灵敏的比色信号报告小分子靶标的存在，用于肉眼检测。该适配体传感器是一种基于 CBSA 酶的传感器，同时具有 CBSA 的目标介导合作行为和 DNA 酶的过氧化物酶模拟催化活性。本发明还提供了使用基于 CBSA 酶的传感器的方法。
• Methods for generating structure-switching aptamers and uses thereof
  申请人：Xiao Yi

  公开号：US11162960B2

  公开（公告）日：2021-11-02

  The subject invention provides methods, assays, and products for detecting small-molecule targets in a complex sample in both clinical and field settings. The subject invention provides aptamer-based sensors and methods of use thereof. The subject invention provides exonuclease-based methods for generating structure-switching aptamers from fully folded or pre-folded aptamers and developing aptamer-based sensors for small-molecule detection. The method for detecting one or more small-molecule targets in a sample comprises contacting the sample with one or more aptamer-based sensor selective for each of the small-molecule targets, and detecting the small-molecule target in the sample.

  本发明提供了在临床和现场环境中检测复杂样本中的小分子靶标的方法、检测方法和产品。本发明提供了基于适配体的传感器及其使用方法。本发明提供了基于外切核酸酶的方法，用于从完全折叠或预折叠的适配体生成结构转换适配体，并开发基于适配体的小分子检测传感器。检测样品中一种或多种小分子靶标的方法包括将样品与一种或多种对每种小分子靶标具有选择性的基于适配体的传感器接触，并检测样品中的小分子靶标。
• VERWENDUNG NIEDRIG-DOSIERTER LOKALANÄSTHETIKA ODER DERIVATE DAVON ZUR THERAPIE CHRONISCHER SCHMERZEN, INSBESONDERE MIGRÄNE
  申请人：Strackharn, Klaus

  公开号：EP2323645A1

  公开（公告）日：2011-05-25