硫汞林

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 硫汞林
• 英文名称: [3-[(3-carboxylato-2,2,3-trimethylcyclopentanecarbonyl)amino]-2-methoxypropyl]mercury(1+);2-sulfanylacetic acid
• 化学式: C16H27HgNO6S
• 分子量: 562.0
• InChiKey: JGMQLDDGSMLGDU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.22
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  7

ADMET

毒理性

• 非人类毒性摘录

水杨酸盐和保泰松的合用明显增加水杨酸盐的毒性。由水杨酸盐和保泰松合用所致的胃肠道出血，在多数病例中，并不伴随着幽门狭窄的既往史，亦无过度用药历史，甚至在停用水杨酸盐和保泰松后，出血仍继续。

Mercurial diuretics, including ... mercaptomerin ... appear to have had no significant adverse effect on the eyes. Intraocular pressure in rabbits was reduced slightly by mercaptomerin or mercuderamide given intramuscularly, but not by topical administration.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

肾脏切片来自狗和老鼠与...巯基甲酚...一起孵化.../和/在2分钟和12分钟时测量吸收速率。 ...巯基甲酚...在两种物种中显著地、剂量相关地抑制了对氯汞苯甲酸（PAH）和N-甲基烟酰胺（NMN）的摄取。 ...鼠组织对巯基甲酚更敏感...

Kidney slices from dogs and rats were incubated with ... mercaptomerin ... /and/ uptake rate was measured at 2 and 12 minutes. ... Mercaptomerin ... produced significant, dose related inhibition of para-chlormercuribenzoate (PAH) and N-methylnicotinamide (NMN) uptake in both species. ... Rat tissue was more sensitive to mercaptomerin ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

2毫升静脉注射的巯基甲酸钠：在24小时内，60-90%通过尿液排出。2毫升皮下注射：2-3小时内50%通过尿液排出。/巯基甲酸钠；来自表格/

2 ML MERCAPTOMERIN SODIUM INJECTED IV: 60-90% EXCRETED IN URINE DURING 24 HR. 2 ML INJECTED SUBCUTANEOUS: 50% EXCRETED IN URINE WITHIN 2-3 HR. /MERCAPTOMERIN SODIUM; FROM TABLE/

来源:Hazardous Substances Data Bank (HSDB)