ethyl 2-fluoromethyl-4-pentenoate | 1131126-05-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 2-fluoromethyl-4-pentenoate
• 英文别名: Ethyl 2-(fluoromethyl)pent-4-enoate；ethyl 2-(fluoromethyl)pent-4-enoate
• CAS: 1131126-05-0
• 化学式: C₈H₁₃FO₂
• 分子量: 160.188
• InChiKey: LARKNPLHOUKYOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  烯丙基三丁基锡 、 ethyl 3-fluoro-2-iodopropanoate 在 偶氮二异丁腈 作用下， 以 苯 为溶剂， 反应 2.0h， 以68%的产率得到ethyl 2-fluoromethyl-4-pentenoate
  参考文献：
  名称：

  Electrochemical iodofluorination of electron-deficient olefins

  摘要：

  Electron-deficient olefins like alpha,beta-unsaturated ester, amide, and phosphonate reacted with iodonium cation species generated by the anodic oxidation of iodide anion in Et3N-5HF/CH3NO2 to form corresponding iodofluorinated compounds in good to moderate yields. The reaction proceeds at room temperature under air atmosphere and constant current conditions. The iodofluorinated products were shown to be useful fluorine-containing building blocks. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.005

文献信息

• Electrochemical fluoro-selenenylation of electron-deficient olefins
  作者：Hirokatsu Nagura、Shinsuke Inagi、Toshio Fuchigami

  DOI：10.1016/j.tet.2008.12.068

  日期：2009.2

  Electrochemical fluoro-selenenylation of electron-deficient olefins like a,p-unsaturated ester, carboxylic acid, amide, and phosphonate was successfully carried out by the anodic oxidation of diphenyl diselenide in the presence of olefins in Et3N center dot 5HF/CH3NO2. The anodically generated benzeneselenenyl fluoride [PhSeF] equivalent was stable in the electrolytic solution, which resulted in the efficient fluoro-selenenylation. The fluoro-selenenylation products were shown to be potential useful fluoro-building blocks. (C) 2008 Elsevier Ltd. All rights reserved.