(E)-diethyl 1-phenylbutenylphosphonate | 1159205-38-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-diethyl 1-phenylbutenylphosphonate
• 英文别名: [(E)-1-[diethoxy(oxido)phosphaniumyl]but-1-enyl]benzene
• CAS: 1159205-38-5
• 化学式: C₁₄H₂₁O₃P
• 分子量: 268.293
• InChiKey: YSDYPHCTPKHZIH-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  41.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-diethyl 1-phenylbutenylphosphonate 在 bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 、 C₄₃H₃₆F₆FeNP₂ 、 氢气 作用下， 以 二氯甲烷 为溶剂， 20.0 ℃ 、6.0 MPa 条件下， 反应 24.0h， 生成 diethyl (1-phenylbutyl)phosphonate 、 diethyl (1-phenylbutyl)phosphonate
  参考文献：
  名称：

  Enantioselective Synthesis of Chiral α-Aryl or α-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic BoPhoz-Type Ligand

  摘要：

  An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.

  DOI：

  10.1021/jo900417m
• 作为产物：
  描述：

  (E)-(1-phenylbut-1-en-1-yl)phosphonic acid 、 原甲酸三乙酯 以 乙醇 为溶剂， 生成 (E)-diethyl 1-phenylbutenylphosphonate
  参考文献：
  名称：

  Enantioselective Synthesis of Chiral α-Aryl or α-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic BoPhoz-Type Ligand

  摘要：

  An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.

  DOI：

  10.1021/jo900417m

文献信息

• Enantioselective Synthesis of Chiral α-Aryl or α-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a <i>P</i>-Stereogenic BoPhoz-Type Ligand
  作者：Dao-Yong Wang、Xiang-Ping Hu、Jun Deng、Sai-Bo Yu、Zheng-Chao Duan、Zhuo Zheng

  DOI：10.1021/jo900417m

  日期：2009.6.5

  An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.