(S)-(+)-(2-benzyloxy-1-methyl)ethyl 4-nitrobenzenesulfonate | 221310-60-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(+)-(2-benzyloxy-1-methyl)ethyl 4-nitrobenzenesulfonate
• 英文别名: [(2S)-1-phenylmethoxypropan-2-yl] 4-nitrobenzenesulfonate
• CAS: 221310-60-7
• 化学式: C₁₆H₁₇NO₆S
• 分子量: 351.38
• InChiKey: PNJXWRSJGQAOLV-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  24.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  95.74
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-(+)-(2-benzyloxy-1-methyl)ethyl 4-nitrobenzenesulfonate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 (R)-(2-benzyloxy-1-methyl)ethyl phenyl ether 、 (S)-(2-benzyloxy-1-methyl)ethyl phenyl ether
  参考文献：
  名称：

  Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies

  摘要：

  Novel acridino- and phenazino-18-crown-6 ligands 5 and 6 were I,prepared from acridine-4.5-diol (9) and phenazine-1,9-diol (10) with tetraethylene glycol di-p-tosylate (11) using potassium tert-butoxide as a bar in THF. New optically pure dimethyl-substituted acridino- and phenazine-18-crown-6 ligands (R,R)-7 and (R,R)-8 were also prepared by treating 9 and 10 with optically pure dimethyl-substituted tetraethylene glycol di-p-tosylate [(S,S)-18], Molecular recognition studies on these novel ligands are underway. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)01128-4
• 作为产物：
  描述：

  (S)-(+)-1-苄氧基-2-丙醇 、 对硝基苯磺酰氯 在 氢氧化钾 作用下， 以 四氢呋喃 为溶剂， 以56%的产率得到(S)-(+)-(2-benzyloxy-1-methyl)ethyl 4-nitrobenzenesulfonate
  参考文献：
  名称：

  Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies

  摘要：

  Novel acridino- and phenazino-18-crown-6 ligands 5 and 6 were I,prepared from acridine-4.5-diol (9) and phenazine-1,9-diol (10) with tetraethylene glycol di-p-tosylate (11) using potassium tert-butoxide as a bar in THF. New optically pure dimethyl-substituted acridino- and phenazine-18-crown-6 ligands (R,R)-7 and (R,R)-8 were also prepared by treating 9 and 10 with optically pure dimethyl-substituted tetraethylene glycol di-p-tosylate [(S,S)-18], Molecular recognition studies on these novel ligands are underway. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)01128-4