6-(2,4-dimethoxyphenyl)-4-phenyl-1H-pyrimidin-2-one | 912960-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(2,4-dimethoxyphenyl)-4-phenyl-1H-pyrimidin-2-one
• CAS: 912960-78-2
• 化学式: C₁₈H₁₆N₂O₃
• 分子量: 308.337
• InChiKey: OYQYXXCCMDGHMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙酮 、 2,4-二甲氧基苯甲醛 、 尿素 在 碘 作用下， 反应 0.13h， 以91%的产率得到6-(2,4-dimethoxyphenyl)-4-phenyl-1H-pyrimidin-2-one
  参考文献：
  名称：

  Iodine-Catalyzed Versatile Synthesis of 4,6-Diarylpyrimidin-2(1H)-ones (DAPMs) via One-Pot, Multicomponent Reaction

  摘要：

  [image omitted] An efficient, solvent-free, one-pot, three-component cyclocondensation reaction between aldehyde, ketone, and urea to give 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using iodine as catalyst is described. This new protocol provides a simple and environmentally benign route along with the associated advantages of good to excellent yield of the products (90-96%) and short reaction times (5-15min) at 80 degrees C.

  DOI：

  10.1080/00397911.2010.493263

文献信息

• TCT (2,4,6-Trichloro-1,3,5-triazine) Promoted Single-Step Syntheis of 4,6-Diarylpyrimidin-2(1H)-ones under Microwave Irradiation
  作者：Ahmad Reza Khosropour、Ahmad R. Khosropour、Iraj Mohammadpoor-Baltork、Mohammad M. Khodaei、Mahbubeh Jokar

  DOI：10.3987/com-05-10613

  日期：——
• Iodine-Catalyzed Versatile Synthesis of 4,6-Diarylpyrimidin-2(1<i>H</i>)-ones (DAPMs) via One-Pot, Multicomponent Reaction
  作者：M. B. Madhusudana Reddy、M. A. Pasha

  DOI：10.1080/00397911.2010.493263

  日期：2011.7.1

  [image omitted] An efficient, solvent-free, one-pot, three-component cyclocondensation reaction between aldehyde, ketone, and urea to give 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using iodine as catalyst is described. This new protocol provides a simple and environmentally benign route along with the associated advantages of good to excellent yield of the products (90-96%) and short reaction times (5-15min) at 80 degrees C.