9-aza-bicyclo[3.3.1]non-2-ene | 4438-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 9-aza-bicyclo[3.3.1]non-2-ene
• 英文别名: 9-Aza-bicyclo[3.3.1]non-2-en；9-Azabicyclo[3.3.1]non-2-ene
• CAS: 4438-27-1
• 化学式: C₈H₁₃N
• mdl: MFCD19218128
• 分子量: 123.198
• InChiKey: ODYAYVUDAZHKHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 9-aza-bicyclo[3.3.1]non-2-ene
  参考文献：
  名称：

  Ciamician; Silber, Gazzetta Chimica Italiana, 1894, vol. 24 II, p. 361

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS HAVING TRPV1 ANTAGONISTIC ACTIVITY AND USES THEREOF<br/>[FR] COMPOSÉS PRÉSENTANT UNE ACTIVITÉ ANTAGONISTE DES TRPV1 ET LEURS UTILISATIONS
  申请人：SHIONOGI & CO

  公开号：WO2011162409A1

  公开（公告）日：2011-12-29

  The invention relates to compounds of Formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof.

  该发明涉及化合物I的公式和其药用可接受的衍生物，包含有效量的化合物I或其药用可接受的衍生物的组合物，以及治疗或预防疼痛、尿失禁、溃疡、炎症性肠病和肠易激综合征等疾病的方法，包括向需要的动物施用化合物I或其药用可接受的衍生物的有效量。
• Bicyclo-octane and bicyclo-nonane derivatives, processes for their preparation and their use as herbicides
  申请人：HER MAJESTY THE QUEEN IN RIGHT OF NEW ZEALAND, DEPARTMENT OF SCIENTIFIC AND INDUSTRIAL RESEARCH, CHEMISTRY DIVISON

  公开号：EP0302599A2

  公开（公告）日：1989-02-08

  Bicyclo-octane and bicyclo-nonane derivatives are described having herbicidal and plant growth regulating properties. The derivatives are based on the general formula

  双环辛烷和双环壬烷衍生物具有除草和植物生长调节性能。这些衍生物基于一般公式。
• [EN] AZABICYCLONONENE DERIVATIVES<br/>[FR] DERIVES D'AZABICYCLONONENE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004096803A1

  公开（公告）日：2004-11-11

  The invention relates to novel 9-azabicyclo[3.3.1 ]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  该发明涉及新型9-氮杂双环[3.3.1]壬烯衍生物及相关化合物，以及它们作为药物组成物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有其中一种或多种化合物的药物组成物，尤其是它们作为肾素抑制剂的用途。
• Azabicyclononene derivatives
  申请人：Bezencon Olivier

  公开号：US20060235044A1

  公开（公告）日：2006-10-19

  The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  本发明涉及新型9-氮杂双环[3.3.1]壬烯衍生物及相关化合物，以及它们作为药物组分在制备药物组合物中的应用。本发明还涉及相关方面，包括制备该化合物的过程，含有这些化合物中的一个或多个的药物组合物，特别是它们作为肾素抑制剂的应用。
• 9-Azabicyclo'3.3.1 inon-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
  申请人：Bezencon Olivier

  公开号：US20060258648A1

  公开（公告）日：2006-11-16

  The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  本发明涉及新型9-氮杂双环[3.3.1]壬烯衍生物及相关化合物，以及它们作为药物组分在制备药物组合物中的应用。本发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，特别是它们作为肾素抑制剂的应用。