(2S,4S,7S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-7-methyl-6-methylene-octan-4-ol | 704882-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4S,7S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-7-methyl-6-methylene-octan-4-ol
• 英文别名: (2S,4S,7S)-2-[tert-butyl(dimethyl)silyl]oxy-7-methyl-6-methylidene-8-phenylmethoxyoctan-4-ol
• CAS: 704882-83-7
• 化学式: C₂₃H₄₀O₃Si
• 分子量: 392.654
• InChiKey: VJUWEORZHXFATH-URVUXULASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.95
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S,4S,7S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-7-methyl-6-methylene-octan-4-ol 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到(2S,4S,7S)-8-Benzyloxy-7-methyl-6-methylene-octane-2,4-diol
  参考文献：
  名称：

  Allyltrichlorostannane additions to chiral aldehydes

  摘要：

  Chiral and achiral allyltrichlorostannanes reacted with chiral beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01713-1
• 作为产物：
  描述：

  (S)-3-((tert-butyldimethylsilyl)oxy)butan-1-ol 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (2S,4S,7S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-7-methyl-6-methylene-octan-4-ol
  参考文献：
  名称：

  Allyltrichlorostannane additions to chiral aldehydes

  摘要：

  Chiral and achiral allyltrichlorostannanes reacted with chiral beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01713-1

文献信息

• Allyltrichlorostannane additions to chiral aldehydes
  作者：Luiz Carlos Dias、Débora Ribeiro dos Santos、Leonardo José Steil

  DOI：10.1016/s0040-4039(03)01713-1

  日期：2003.9

  Chiral and achiral allyltrichlorostannanes reacted with chiral beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.