ethyl 4-methyl-6-(4-nitrophenyl)-2-(piperidin-1-ylthio)pyrimidine-5-carboxylate | 1427279-32-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: ethyl 4-methyl-6-(4-nitrophenyl)-2-(piperidin-1-ylthio)pyrimidine-5-carboxylate
• CAS: 1427279-32-0
• 化学式: C₁₉H₂₂N₄O₄S
• 分子量: 402.474
• InChiKey: WHUMRZGYCSDGBG-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  哌啶 、 6-methyl-4-(4-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 在 碘 、 caesium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以70%的产率得到ethyl 4-methyl-6-(4-nitrophenyl)-2-(piperidin-1-ylthio)pyrimidine-5-carboxylate
  参考文献：
  名称：

  Molecular iodine-mediated S–N and C–N cross-coupling and oxidative aromatization of 3,4-dihydropyrimidin-2(1H)-thiones with secondary amines

  摘要：

  A domino S-N and C-N coupling/oxidative aromatization process to synthesize 2-aminothio-phenylpyrimidines and 2-amino-phenylpyrimidines by S-N and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and secondary amines catalyzed by molecular iodine. Remarkably the C-N coupled product was obtained via a desulfitative coupling-aromatization reaction in one-pot reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.113