4-[4-[4-[4-[4-[4-(3-Carboxypropanoylamino)anilino]anilino]anilino]anilino]anilino]-4-oxobutanoic acid | 213540-68-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-[4-[4-[4-[4-(3-Carboxypropanoylamino)anilino]anilino]anilino]anilino]anilino]-4-oxobutanoic acid
• 英文别名: 4-[4-[4-[4-[4-[4-(3-carboxypropanoylamino)anilino]anilino]anilino]anilino]anilino]-4-oxobutanoic acid
• CAS: 213540-68-2
• 化学式: C₃₈H₃₆N₆O₆
• 分子量: 672.74
• InChiKey: NYQQSXWJXJGFEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  50
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  181
• 氢给体数：
  8
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-oxo-4-(4-(phenylamino)phenylamino)butanoic acid 、 对苯二胺 在 盐酸 、 ammonium persulfate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以54%的产率得到4-[4-[4-[4-[4-[4-(3-Carboxypropanoylamino)anilino]anilino]anilino]anilino]anilino]-4-oxobutanoic acid
  参考文献：
  名称：

  Biodegradable electroactive polymers for electrochemically-triggered drug delivery

  摘要：

  我们报道了可生物降解的电活性聚合物（EAP）材料及其作为药物输送装置的应用。

  DOI：

  10.1039/c4tb00355a

文献信息

• [EN] DRUG DELIVERY USING ELECTROCHEMICALLY-TRIGGERED BIODEGRADABLE ELECTROACTIVE MATERIALS<br/>[FR] ADMINISTRATION DE MÉDICAMENT AU MOYEN DE MATIÈRES ÉLECTROACTIVES BIODÉGRADABLES À DÉCLENCHEMENT PAR VOIE ÉLECTROCHIMIQUE
  申请人：UNIV FLORIDA

  公开号：WO2015143334A1

  公开（公告）日：2015-09-24

  Embodiments of the present disclosure provide for biodegradable electroactive materials, methods of making biodegradable electroactive material, methods of using biodegradable electroactive material, method of delivering a dopant such as a drug to a patient using the biodegradable electroactive material.

  本公开的实施例提供了可生物降解的电活性材料，制备可生物降解的电活性材料的方法，使用可生物降解的电活性材料的方法，以及利用可生物降解的电活性材料向患者输送掺杂物（如药物）的方法。
• Enhanced Electrical Conductivity by Macromolecular Architecture: Hyperbranched Electroactive and Degradable Block Copolymers Based on Poly(ε-caprolactone) and Aniline Pentamer
  作者：Baolin Guo、Anna Finne-Wistrand、Ann-Christine Albertsson

  DOI：10.1021/ma100530k

  日期：2010.5.25

  We present macromolecular architecture design as a useful tool to enhance the conductivity of degradable polymers. Linear and hyperbranched copolymers with electrical conductivity and biodegradability were synthesized by an "A(2) + B-n (n=2, 3, 4)" strategy using carboxyl-capped aniline pen tamer (CCAP) and branched poly(epsilon-caprolactone)s (PCLs) by coupling reactions. A more hydrophilic surface and lower crystallinity of the doped emeraldine state of aniline pentamer (EM A P) copolymer was achieved compared with PCLs, and TGA results demonstrated that the CCAP contents in the copolymers were almost the same. The structure of the polymers was characterized by FT-IR. NMR, and SEC. Good electroactivity of the copolymers was confirmed by UV and cyclic voltammetry (CV), and CV showed three pairs of redox peaks. The hyperbranched copolymers had a higher conductivity than the linear ones. It is suggested that the higher conductivity of the hyperbranched copolymer is due to the ordered distribution of peripheral EMAP segments that more easily form a conductive network. Therefore, the conductivity of the polymers is improved and controlled by the macromolecular architecture.
• Facile and Green Approach towards Electrically Conductive Hemicellulose Hydrogels with Tunable Conductivity and Swelling Behavior
  作者：Weifeng Zhao、Lidija Glavas、Karin Odelius、Ulrica Edlund、Ann-Christine Albertsson

  DOI：10.1021/cm501852w

  日期：2014.7.22

  A one-pot reaction to synthesize electrically conductive hemicellulose hydrogels (ECHHs) is developed via a facile and green approach in water and at ambient temperature. ECHHs were achieved by cross-linking O-acetyl-galactoglucomannan (AcGGM) with epichlorohydrin in the presence of conductive aniline pentamer (AP) and were confirmed by infrared spectroscopy (IR) and elemental analysis. All hydrogels had macro-porous structures, and the thermal stability of ECHHs was improved by the addition of AP. Hydrogel equilibrium swelling ratios (ESRs) varied from 13.7 to 11.4 and were regulated by cross-linker concentration. The ESRs can also be tuned from 9.6 to 6.0 by changing the AP content level from 10 to 40% (w/w) while simultaneously altering conductivity from 9.05 x 10(-9) to 1.58 X 10(-6) S/cm. ECHHs with controllable conductivity, tunable swelling behavior, and acceptable mechanical properties have great potential for biomedical applications, such as biosensors, electronic devices, and tissue engineering.
• Biodegradable electroactive polymers for electrochemically-triggered drug delivery
  作者：John G. Hardy、David J. Mouser、Netzahualcóyotl Arroyo-Currás、Sydney Geissler、Jacqueline K. Chow、Lindsey Nguy、Jong M. Kim、Christine E. Schmidt

  DOI：10.1039/c4tb00355a

  日期：——

  We report biodegradable electroactive polymer (EAP)-based materials and their application as drug delivery devices.

  我们报道了可生物降解的电活性聚合物（EAP）材料及其作为药物输送装置的应用。