2-Bromo-N-[2-(5-chloro-2-hydroxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide | 761442-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Bromo-N-[2-(5-chloro-2-hydroxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide
• CAS: 761442-94-8
• 化学式: C₁₆H₁₀BrClF₃NO₃
• 分子量: 436.613
• InChiKey: QBYCFHFJPGMRNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-Bromo-N-[2-(5-chloro-2-hydroxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide 在 sodium hydride 、 tin(ll) chloride 作用下， 以 四氢呋喃 、 吡啶 、 乙醇 为溶剂， 生成 N-[4-[[4-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]-thio]=phenyl]-1,1,1-trifluoromethanesulfonamide
  参考文献：
  名称：

  3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

  摘要：

  A series of Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinone core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavernosum tissue strips confirms the potential to effect therapy for ED, the effect being maximal for the 3-amino-2-hydroxy thiol side chain. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.080
• 作为产物：
  描述：

  2-bromo-N-[2-(5-chloro-2-methoxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以91%的产率得到2-Bromo-N-[2-(5-chloro-2-hydroxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide
  参考文献：
  名称：

  4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle

  摘要：

  A novel series of 4-aryl-3-(mercapto)quinolin-2-one derivatives was prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. In vivo efficacy has been demonstrated with a selective maxi-K opening relaxant in a rat model of erectile function. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.051