5-(2-(3-(2-(4-aminopiperidin-1-yl)-2-oxoethyl)ureido)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide | 1240282-55-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(2-(3-(2-(4-aminopiperidin-1-yl)-2-oxoethyl)ureido)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide
• 英文别名: 1-[2-(4-Aminopiperidin-1-yl)-2-oxoethyl]-3-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]urea
• CAS: 1240282-55-6
• 化学式: C₂₃H₃₁N₉O₄S
• 分子量: 529.623
• InChiKey: MUTVRNYEPQOTCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  185
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] UREA TRIAZOLOLO [1, 5-A] PYRIDINE DERIVATIVES AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS D'URÉE-TRIAZOLO[1,5-A]PYRIDINE EN TANT QU'INHIBITEURS DE PI3K
  申请人：CELLZOME LTD

  公开号：WO2010092015A1

  公开（公告）日：2010-08-19

  The invention relates to compounds of formula (I) wherein X1,R and R1 to R4 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.