N-({5-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-(2,6-dimethylpyridin-4-yl)-3-fluorophenyl}methyl)-3,3,3-trifluoropropanamide | 1394908-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-({5-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-(2,6-dimethylpyridin-4-yl)-3-fluorophenyl}methyl)-3,3,3-trifluoropropanamide
• 英文别名: N-[[5-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-(2,6-dimethylpyridin-4-yl)-3-fluorophenyl]methyl]-3,3,3-trifluoropropanamide
• CAS: 1394908-76-9
• 化学式: C₂₃H₂₇F₄N₃O₂
• 分子量: 453.48
• InChiKey: GDOVJMJBCDXNTE-IYBDPMFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• (PYRIDIN-4-YL)BENZYLAMIDES AS ALLOSTERIC MODULATORS OF ALPHA 7 nAChR
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2678315A2

  公开（公告）日：2014-01-01
• (Pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nAChR
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2678315B1

  公开（公告）日：2015-12-16
• [EN] (PYRIDIN-4-YL)BENZYLAMIDES AS ALLOSTERIC MODULATORS OF ALPHA 7 nAChR<br/>[FR] (PYRIDIN-4-YL)BENZYLAMIDES EN TANT QUE MODULATEURS ALLOSTÉRIQUES D'ALPHA-7-NACHR
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012113850A2

  公开（公告）日：2012-08-30

  The present invention relates to (pyridin-4-yl)benzylamides derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulators having the capability to increase the efficacy of nicotinic receptor agonists.