ethyl (2R,3R)-3-[[(2S)-1-(naphthalen-2-ylmethylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate | 959925-80-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl (2R,3R)-3-[[(2S)-1-(naphthalen-2-ylmethylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
• CAS: 959925-80-5
• 化学式: C₂₂H₂₆N₂O₅
• 分子量: 398.459
• InChiKey: UPLWPMPAIOTRRH-IPMKNSEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• EPOXIDE INHIBITORS OF CYSTEINE PROTEASES
  申请人：Bogyo Matthew S.

  公开号：US20080176841A1

  公开（公告）日：2008-07-24

  Provided herein are novel epoxide inhibitors of cysteine proteases, compositions comprising the epoxide inhibitors, and packaged pharmaceuticals. Also provided are methods of inhibiting a papain-family cysteine protease and methods of treating or preventing a disease by administering a composition containing an epoxide inhibitor of the invention. The compositions may be administered in combination with another therapeutic agent.