Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-methylene-, iodide (1:1), (5alpha)- | 136440-71-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-methylene-, iodide (1:1), (5alpha)-
• 英文别名: (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-3-methyl-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-4a,9-diol;iodide
• CAS: 136440-71-6
• 化学式: C22H28INO3
• 分子量: 481.4
• InChiKey: TYVHPUCHIBHVEV-ZTKPOCDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.34
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• (R)-N-STEREOISOMERS OF 7,8-SATURATED-4,5-EPOXY-MORPHINANIUM ANALOGS
  申请人：Progenics Pharmaceuticals, Inc.

  公开号：EP2101773A2

  公开（公告）日：2009-09-23
• (R)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
  申请人：Perez Julio

  公开号：US20090047279A1

  公开（公告）日：2009-02-19

  Novel (R)—N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (R)—N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, opioid-induced constipation.
• [EN] (R)-N-STEREOISOMERS OF 7,8-SATURATED-4,5-EPOXY-MORPHINANIUM ANALOGS<br/>[FR] (R)-N-STÉRÉOISOMÈRES D'ANALOGUES 4,5-ÉPOXY-MORPHINANIUM SATURÉ EN POSITION 7 ET 8
  申请人：PROGENICS PHARM INC

  公开号：WO2008064351A2

  公开（公告）日：2008-05-29

  [EN] Novel (R)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (R)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, opioid-induced constipation.
  [FR] La présente invention concerne de nouveaux (R)-N-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8. La présente invention concerne également des compositions pharmaceutiques contenant les (R)-N-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8 et leurs procédés d'utilisation pharmaceutique. De tels analogues sont décrits comme étant utiles dans le traitement, parmi des conditions variables, de la constipation induite par l'opioïde.